小唾液腺分泌性癌:深度病例报告

IF 5.4 3区 材料科学 Q2 CHEMISTRY, PHYSICAL
Reydson Alcides de Lima-Souza , Iara Vieira Ferreira , Carlos Takahiro Chone , Erika Said Abu Egal , Alena Skálová , Albina Altemani , Fernanda Viviane Mariano
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引用次数: 0

摘要

一名 56 岁的女性被转诊到我院,要求治疗曾在另一家医院进行过活检的边缘受损的恶性唾液腺肿瘤。患者称其口腔病变已有二十年历史,过去两年来病变逐渐增大,并伴有局部疼痛和呼吸困难。体格检查发现,左侧软腭和扁桃体支柱处有一个约 3 厘米的红斑、溃疡和出血病灶。计算机断层扫描显示,左侧软腭地形呈扩张性病变,主要向鼻咽腔方向生长,并部分侵入该区域的左侧壁。患者接受了手术,组织病理学检查显示,这是一种浸润性和侵袭性上皮肿瘤,具有大量空泡和嗜酸性胞质、水泡状细胞核和突出的核小体。肿瘤细胞呈实性、微囊性、管状和滤泡状排列,管腔内有嗜酸性分泌物。有丝分裂现象频繁,所有边缘都受到肿瘤的影响。形态学和免疫组化特征支持分泌性癌的诊断,目前正在对患者进行进一步的治疗干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Secretory carcinoma of the minor salivary gland: An in-depth case report

A 56-year-old female was referred to our service for management of a malignant salivary gland neoplasm with compromised margins that had been biopsied previously at another service. The patient reported a twenty-year history of a lesion in the oral cavity with progressive and exuberant growth over the past two years, associated with local pain and dyspnea. Physical examination revealed an erythematous, ulcerated, and hemorrhagic lesion measuring approximately 3 cm on the left soft palate and tonsillar pillar. Computed tomography revealed an expansile lesion in the topography of the left soft palate, growing predominantly toward the lumen of the nasopharynx and partially invading the left wall of this region. The patient underwent surgery and histopathologic examination revealed an infiltrative and aggressive epithelial neoplasia with large vacuolated and eosinophilic cytoplasm, vesicular nuclei, and prominent nucleoli. The neoplastic cells were arranged in a solid, microcystic, tubular, and follicular pattern with eosinophilic luminal secretion. Mitotic figures were frequent and all margins were affected by the neoplasia. Morphologic and immunohistochemical features supported the diagnosis of secretory carcinoma, and the patient is currently being followed for further therapeutic intervention.

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来源期刊
ACS Applied Energy Materials
ACS Applied Energy Materials Materials Science-Materials Chemistry
CiteScore
10.30
自引率
6.20%
发文量
1368
期刊介绍: ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
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