可注射的透明质酸-聚脱氧核糖核苷酸（HA-PDRN）交联水凝胶作为皮肤填充剂

IF 5.8 2区化学 Q1 POLYMER SCIENCE

European Polymer Journal Pub Date : 2024-08-19 DOI:10.1016/j.eurpolymj.2024.113395

Guo jiahong , Fang wei , Wang feifei

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引用次数: 0

摘要

可注射水凝胶通常用作皮肤填充剂，在增加组织容积和矫正皱纹方面显示出巨大的潜力。HA（透明质酸）被广泛用于皮肤填充剂，但需要进行大量改良才能满足对有效性和功能性的商业要求。PDRN（聚脱氧核苷酸）是从鲑鱼精子细胞中提取的 DNA，具有多种治疗功效，包括抗炎和刺激胶原蛋白。本研究提出了一种基于 HA 和 PDRN 的新型交联水凝胶。HA-PDRN 交联水凝胶是通过 HA 的羧基和 PDRN 的氨基之间的共价相互作用制成的，具有理想的特性，如粘弹性、外观、水合性、降解性、注射性和生物相容性。对小鼠进行的体内研究表明，这些水凝胶可在 24 周内保持体积，减少炎症，促进胶原蛋白合成，同时还具有耐久性、安全性和可支撑性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

An injectable hyaluronic acid-Polydeoxyribonucleotides (HA-PDRN) crosslinked hydrogel as a dermal filler

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An injectable hyaluronic acid-Polydeoxyribonucleotides (HA-PDRN) crosslinked hydrogel as a dermal filler

Injectable hydrogels, commonly utilized as dermal fillers, show great potential for increasing tissue volume and correcting wrinkles. HA (hyaluronic acid), extensively used in dermal fillers, requires considerable modifications to meet commercial demands for effectiveness and functionality. PDRN (polydeoxyribonucleotides), DNA extracted from salmon sperm cells, offer several therapeutic benefits, including anti-inflammatory and collagen stimulation. This work presents a new crosslinked hydrogel based on HA and PDRN. HA-PDRN crosslinked hydrogels were fabricated via covalent interactions between the carboxyl groups of HA and amino groups of PDRN, resulting in desirable properties such as viscoelasticity, appearance, hydration, degradation, injectability, and biocompatibility. In vivo studies on mice revealed that these hydrogels maintain volume for over 24 weeks, with reduced inflammation and enhanced collagen synthesis, as well as exhibiting durability, safety, and supportability.

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来源期刊

European Polymer Journal 化学-高分子科学

CiteScore

9.90

自引率

10.00%

发文量

691

审稿时长

23 days

期刊介绍： European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas: Polymer synthesis and functionalization • Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers. Stimuli-responsive polymers • Including shape memory and self-healing polymers. Supramolecular polymers and self-assembly • Molecular recognition and higher order polymer structures. Renewable and sustainable polymers • Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites. Polymers at interfaces and surfaces • Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications. Biomedical applications and nanomedicine • Polymers for regenerative medicine, drug delivery molecular release and gene therapy The scope of European Polymer Journal no longer includes Polymer Physics.