长期抗逆转录病毒疗法使艾滋病毒特异性 CD8+ T 细胞反应恢复活力

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2024-08-23 DOI:10.1038/s41590-024-01924-8

Joel N. Blankson

引用次数: 0

摘要

大多数艾滋病毒感染者的艾滋病毒特异性 CD8+ T 细胞功能失调。然而，长期接受抗逆转录病毒疗法可大大改善这些细胞的抗病毒功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Long-term antiretroviral therapy rejuvenates the HIV-specific CD8+ T cell response

查看原文本刊更多论文

Long-term antiretroviral therapy rejuvenates the HIV-specific CD8+ T cell response

HIV-specific CD8+ T cells are dysfunctional in the majority of people living with HIV. However, long-term treatment with antiretroviral therapy may considerably improve the antiviral function of these cells.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.