Elliott Lyles, Carol Stegura, Luke Broughton, Alan Snyder, Todd Schlesinger
{"title":"干细胞、富血小板血浆和外泌体的基础科学与原理","authors":"Elliott Lyles, Carol Stegura, Luke Broughton, Alan Snyder, Todd Schlesinger","doi":"10.1002/der2.258","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Regenerative medicine seeks to harness the natural healing abilities of the body and has scope for use in the treatment of dermatologic conditions. Stem cell therapy, platelet-rich plasma (PRP), and exosomes are emerging as key components in regenerative medicine, particularly in skin rejuvenation and repair.</p>\n </section>\n \n <section>\n \n <h3> Objectives</h3>\n \n <p>The goal of this article is to review the basic science behind the function of stem cells, PRP, and exosomes in regenerative medicine.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A literature review was conducted using PubMed and Google Scholar, focusing on basic science literature regarding the structure, origin, mechanisms of action, and isolation of stem cells, PRP, and exosomes.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The evaluation found that stem cells facilitate skin regeneration by modulating the inflammatory milieu. PRP was shown to have positive effects on repairing skin elasticity and improving scars through the release of growth factors. Exosomes were found to enhance fibroblast proliferation and collagen synthesis.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Stem cell therapy, PRP, and exosomes each show mechanisms that render them useful in regenerative medicine. Future research is needed to further elucidate their mechanisms of action, standardize their isolation procedures, and optimize their potential for clinical application.</p>\n </section>\n </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 4","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.258","citationCount":"0","resultStr":"{\"title\":\"Basic Science and Principles of Stem Cells, Platelet-Rich Plasma, and Exosomes\",\"authors\":\"Elliott Lyles, Carol Stegura, Luke Broughton, Alan Snyder, Todd Schlesinger\",\"doi\":\"10.1002/der2.258\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Regenerative medicine seeks to harness the natural healing abilities of the body and has scope for use in the treatment of dermatologic conditions. Stem cell therapy, platelet-rich plasma (PRP), and exosomes are emerging as key components in regenerative medicine, particularly in skin rejuvenation and repair.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>The goal of this article is to review the basic science behind the function of stem cells, PRP, and exosomes in regenerative medicine.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A literature review was conducted using PubMed and Google Scholar, focusing on basic science literature regarding the structure, origin, mechanisms of action, and isolation of stem cells, PRP, and exosomes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The evaluation found that stem cells facilitate skin regeneration by modulating the inflammatory milieu. PRP was shown to have positive effects on repairing skin elasticity and improving scars through the release of growth factors. Exosomes were found to enhance fibroblast proliferation and collagen synthesis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Stem cell therapy, PRP, and exosomes each show mechanisms that render them useful in regenerative medicine. Future research is needed to further elucidate their mechanisms of action, standardize their isolation procedures, and optimize their potential for clinical application.</p>\\n </section>\\n </div>\",\"PeriodicalId\":100366,\"journal\":{\"name\":\"Dermatological Reviews\",\"volume\":\"5 4\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.258\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatological Reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/der2.258\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatological Reviews","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/der2.258","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Basic Science and Principles of Stem Cells, Platelet-Rich Plasma, and Exosomes
Background
Regenerative medicine seeks to harness the natural healing abilities of the body and has scope for use in the treatment of dermatologic conditions. Stem cell therapy, platelet-rich plasma (PRP), and exosomes are emerging as key components in regenerative medicine, particularly in skin rejuvenation and repair.
Objectives
The goal of this article is to review the basic science behind the function of stem cells, PRP, and exosomes in regenerative medicine.
Methods
A literature review was conducted using PubMed and Google Scholar, focusing on basic science literature regarding the structure, origin, mechanisms of action, and isolation of stem cells, PRP, and exosomes.
Results
The evaluation found that stem cells facilitate skin regeneration by modulating the inflammatory milieu. PRP was shown to have positive effects on repairing skin elasticity and improving scars through the release of growth factors. Exosomes were found to enhance fibroblast proliferation and collagen synthesis.
Conclusions
Stem cell therapy, PRP, and exosomes each show mechanisms that render them useful in regenerative medicine. Future research is needed to further elucidate their mechanisms of action, standardize their isolation procedures, and optimize their potential for clinical application.
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