有倒刺末端的肌动蛋白丝动力学:新结构、新见解

IF 6 2区 生物学 Q1 CELL BIOLOGY
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引用次数: 0

摘要

动态肌动蛋白细胞骨架为大多数细胞的形态提供了结构支撑,促进了细胞内运输,并产生了细胞运动和分裂所需的力量,从而为许多关键的生物过程做出了贡献。为了执行其中的许多功能,肌动蛋白单体聚合成极化丝,极化丝的两端具有不同的结构和生化特性。丝的动态受多种调节蛋白的调控,它们共同决定丝的伸长率和分解率,尤其是在快速生长的倒钩(加)端。本综述重点介绍了六种带刺末端调节蛋白的生化机制:甲形蛋白、异形蛋白、封端蛋白、IQGAP1、环化酶相关蛋白和双蛋白。我们讨论了单个蛋白如何影响肌动蛋白动力学,以及几种引人入胜的复杂组合如何影响肌动蛋白丝的聚合命运。了解这些机制有助于深入了解肌动蛋白在重要细胞过程中的调控方式以及在疾病中的失调方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Actin filament dynamics at barbed ends: New structures, new insights

The dynamic actin cytoskeleton contributes to many critical biological processes by providing the structural support underlying the morphology of most cells, facilitating intracellular transport, and generating forces required for cell motility and division. To execute many of these functions, actin monomers polymerize into polarized filaments that display different structural and biochemical properties at each end. Filament dynamics are regulated by diverse regulatory proteins which collaborate to dictate rates of elongation and disassembly, particularly at the fast-growing barbed (plus) end. This review highlights the biochemical mechanisms of six barbed end regulatory proteins: formin, profilin, capping protein, IQGAP1, cyclase-associated protein, and twinfilin. We discuss how individual proteins influence actin dynamics and how several intriguing complex assemblies influence the polymerization fate of actin filaments. Understanding these mechanisms offers insights into how actin is regulated in essential cell processes and dysregulated in disease.

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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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