同时进行肝脏和肾脏移植手术后的掩蔽性肾脏同种异体移植失败:病例报告

Kasra Shirini , Ujwal Gautam , Hiba Ahmed , Raphael P.H. Meier , Cinthia Drachenberg , Abdolreza Haririan
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引用次数: 0

摘要

近年来,由于肝移植候选者中肾功能不全的发病率不断上升,肝肾同时移植(SLK)的肾脏利用率显著增加。然而,相当一部分肝肾同时移植受者在移植后会出现肾功能恢复,从而导致肾移植的不必要。本病例报告介绍了一例显著的原生肾功能恢复病例,该病例是在 SLK 受体移植 11 年后发现的,当时发现移植肾发生了广泛的纤维化和萎缩,被原生肾功能恢复所掩盖。这个病例凸显了评估 SLK 候选者所面临的挑战,以及需要改进工具来预测原生肾脏的恢复情况。对于那些肾功能未恢复的患者,应更多地利用安全网机制,以避免不必要地使用稀缺的同种异体肾脏,因为肾衰竭候选患者急需同种异体肾脏。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Masked kidney allograft failure after simultaneous liver and kidney transplantation: A case report

Kidney utilization for simultaneous liver-kidney transplantation (SLK) has seen a significant increase in recent years, driven by the rising prevalence of renal dysfunction among liver transplant candidates. However, a substantial proportion of SLK recipients experience native kidney function recovery post-transplant, rendering the kidney transplant unnecessary. This case report presents a remarkable instance of native renal function recovery in a SLK recipient, discovered eleven years after transplantation, when the transplanted kidney was found to have undergone extensive fibrosis and atrophy, masked by native kidney recovery. This case highlights the challenges posed by evaluation of SLK candidates and the need for improved tools to predict native kidney recovery. Safety net mechanism for those who do not recover kidney function should be utilized more to avoid the unnecessary utilization of scarce kidney allografts, which are critically needed for waitlisted patients with kidney failure.

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