卡贾尔间质细胞的起源与发展

Tara Sweet, Christeen M Abraham, Adam Rich
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引用次数: 0

摘要

消化道是一系列具有特殊功能和专门解剖结构的器官。每个器官都有类似的上皮组织、结缔组织、平滑肌和神经组织的同心层。卡贾尔间质细胞(ICC)分布在平滑肌层中,有助于组织平滑肌的重复性和节律性收缩。了解 ICC 的发育对了解胃肠道运动模式至关重要。本文介绍了确定小鼠、鸡和人类 ICC 起源和发育的实验,以及对斑马鱼的了解。已描述了消化道中至少六种类型的 ICC,并回顾了成体组织中 ICC 的异质性。文中还描述了 ICC 发育和维持 ICC 亚类所需的因素。这篇综述适合那些刚接触 ICC 发育和生理学的人,尤其是那些专注于使用斑马鱼和其他模型系统的人。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Origin and Development of Interstitial Cells of Cajal.

The digestive tract is a series of organs with specific functions and specialized anatomy. Each organ is organized similarly with concentric layers of epithelial, connective, smooth muscle, and neural tissues. Interstitial cells of Cajal (ICC) are distributed in smooth muscle layers and contribute to the organization of repetitive and rhythmic smooth muscle contractions. Understanding ICC development is critical to understanding gastrointestinal motility patterns. Experiments determining ICC origin and development in mice, chicken, and humans are described, as well as what is known in the zebrafish. At least six types of ICC in the digestive tract have been described and ICC heterogeneity in adult tissues is reviewed. Factors required for ICC development and for maintenance of ICC subclasses are described. This review is suitable for those new to ICC development and physiology, especially those focused on using zebrafish and other model systems.

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