肿瘤自由生长建模:解读癌症发展的离散、连续和混合方法。

IF 2.6 4区 工程技术 Q1 Mathematics
Dashmi Singh, Dana Paquin
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引用次数: 0

摘要

肿瘤生长动力学是了解癌症进展和治疗反应的一个重要方面,可缓解医疗保健领域最紧迫的挑战之一。通过计算理解肿瘤行为的硅学方法提供了一种高效、经济的方法,可替代湿实验室检查,并能适应不同的环境条件、时间尺度和独特的患者参数。因此,本文探讨了癌症中肿瘤自由生长的建模问题,调查了有关连续、离散和混合方法的当代文献。在这些模型中,预测能力和高分辨率模拟等因素与模拟负荷和参数可行性等缺点相互竞争。了解肿瘤在不同情况和背景下的行为,是推动癌症研究和革新临床结果的第一步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modeling free tumor growth: Discrete, continuum, and hybrid approaches to interpreting cancer development.

Tumor growth dynamics serve as a critical aspect of understanding cancer progression and treatment response to mitigate one of the most pressing challenges in healthcare. The in silico approach to understanding tumor behavior computationally provides an efficient, cost-effective alternative to wet-lab examinations and are adaptable to different environmental conditions, time scales, and unique patient parameters. As a result, this paper explored modeling of free tumor growth in cancer, surveying contemporary literature on continuum, discrete, and hybrid approaches. Factors like predictive power and high-resolution simulation competed against drawbacks like simulation load and parameter feasibility in these models. Understanding tumor behavior in different scenarios and contexts became the first step in advancing cancer research and revolutionizing clinical outcomes.

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来源期刊
Mathematical Biosciences and Engineering
Mathematical Biosciences and Engineering 工程技术-数学跨学科应用
CiteScore
3.90
自引率
7.70%
发文量
586
审稿时长
>12 weeks
期刊介绍: Mathematical Biosciences and Engineering (MBE) is an interdisciplinary Open Access journal promoting cutting-edge research, technology transfer and knowledge translation about complex data and information processing. MBE publishes Research articles (long and original research); Communications (short and novel research); Expository papers; Technology Transfer and Knowledge Translation reports (description of new technologies and products); Announcements and Industrial Progress and News (announcements and even advertisement, including major conferences).
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