{"title":"评估含有不同浓度光活化氧化锌纳米粒子的正畸树脂复合材料对陶瓷和金属正畸托槽周围变异链球菌生物膜的物理机械、抗菌和抗脱矿特性：一项体外研究。","authors":"Yasamin Babaee Hemmati , Rashin Bahrami , Maryam Pourhajibagher","doi":"10.1016/j.ortho.2024.100901","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and purpose</h3><p>The aim of this study was to evaluate the physico-mechanical, anti-bacterial, and anti-demineralization properties of orthodontic resin composite containing photoactivated zinc oxide nanoparticles (ZnONPs) on <em>Streptococcus mutans</em> biofilm around ceramic and metal brackets.</p></div><div><h3>Material and methods</h3><p>Following the minimum inhibitory concentration (MIC) determination for ZnONPs, shear bond strength (SBS) was tested for composites containing different concentrations of ZnONPs. The chosen concentration was used to evaluate the microleakage, anti-bacterial, and anti-demineralization properties.</p></div><div><h3>Results</h3><p>Adding 50<!--> <!-->μg/mL of ZnONPs to the orthodontic composite did not negatively affect its physico-mechanical properties. ZnONPs (50<!--> <!-->μg/mL)-mediated aPDT and 0.2% chlorhexidine significantly (<em>P</em> <!-->=<!--> <!-->0.000) reduced <em>S. mutans</em> biofilms compared to the phosphate-buffered saline (PBS) groups (metal/PBS<!--> <!-->=<!--> <!-->7.47<!--> <!-->±<!--> <!-->0.7<!--> <!-->×<!--> <!-->10<sup>6</sup>, and ceramic/PBS<!--> <!-->=<!--> <!-->7.47<!--> <!-->±<!--> <!-->0.7<!--> <!-->×<!--> <!-->10<sup>6</sup>), with the lowest colony count observed in these groups (metal/chlorhexidine<!--> <!-->=<!--> <!-->1.06<!--> <!-->±<!--> <!-->0.4<!--> <!-->×<!--> <!-->10<sup>5</sup>, ceramic/chlorhexidine<!--> <!-->=<!--> <!-->1<!--> <!-->±<!--> <!-->0.2<!--> <!-->×<!--> <!-->10<sup>5</sup>, metal/ZnONPs-mediated aPDT<!--> <!-->=<!--> <!-->1.33<!--> <!-->±<!--> <!-->0.3<!--> <!-->×<!--> <!-->10<sup>5</sup>, and ceramic/ZnONPs-mediated aPDT<!--> <!-->=<!--> <!-->1.2<!--> <!-->±<!--> <!-->0.3<!--> <!-->×<!--> <!-->10<sup>5</sup>). Sodium fluoride varnish and ZnONPs-mediated aPDT showed the highest efficacy in anti-demineralization and significantly improving the enamel surface microhardness compared to the artificial saliva, especially in ceramic bracket groups (524.17<!--> <!-->±<!--> <!-->42.78<!--> <!-->N and 441.00<!--> <!-->±<!--> <!-->29.48<!--> <!-->N, 394.17<!--> <!-->±<!--> <!-->46.83<!--> <!-->N, <em>P</em> <!-->=<!--> <!-->0.000, and <em>P</em> <!-->=<!--> <!-->0.003, respectively).</p></div><div><h3>Conclusion</h3><p>ZnONPs (50<!--> <!-->μg/mL)-mediated aPDT effectively inhibited <em>S. mutans</em> biofilm and promoted anti-demineralization without adverse effects on the physico-mechanical properties of the composite resin. These results suggest the potential of this method in preventing white spot lesions during orthodontic treatment.</p></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"22 4","pages":"Article 100901"},"PeriodicalIF":1.8000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessing the physico-mechanical, anti-bacterial, and anti-demineralization properties of orthodontic resin composite containing different concentrations of photoactivated zinc oxide nanoparticles on Streptococcus mutans biofilm around ceramic and metal orthodontic brackets: An ex vivo study\",\"authors\":\"Yasamin Babaee Hemmati , Rashin Bahrami , Maryam Pourhajibagher\",\"doi\":\"10.1016/j.ortho.2024.100901\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and purpose</h3><p>The aim of this study was to evaluate the physico-mechanical, anti-bacterial, and anti-demineralization properties of orthodontic resin composite containing photoactivated zinc oxide nanoparticles (ZnONPs) on <em>Streptococcus mutans</em> biofilm around ceramic and metal brackets.</p></div><div><h3>Material and methods</h3><p>Following the minimum inhibitory concentration (MIC) determination for ZnONPs, shear bond strength (SBS) was tested for composites containing different concentrations of ZnONPs. The chosen concentration was used to evaluate the microleakage, anti-bacterial, and anti-demineralization properties.</p></div><div><h3>Results</h3><p>Adding 50<!--> <!-->μg/mL of ZnONPs to the orthodontic composite did not negatively affect its physico-mechanical properties. ZnONPs (50<!--> <!-->μg/mL)-mediated aPDT and 0.2% chlorhexidine significantly (<em>P</em> <!-->=<!--> <!-->0.000) reduced <em>S. mutans</em> biofilms compared to the phosphate-buffered saline (PBS) groups (metal/PBS<!--> <!-->=<!--> <!-->7.47<!--> <!-->±<!--> <!-->0.7<!--> <!-->×<!--> <!-->10<sup>6</sup>, and ceramic/PBS<!--> <!-->=<!--> <!-->7.47<!--> <!-->±<!--> <!-->0.7<!--> <!-->×<!--> <!-->10<sup>6</sup>), with the lowest colony count observed in these groups (metal/chlorhexidine<!--> <!-->=<!--> <!-->1.06<!--> <!-->±<!--> <!-->0.4<!--> <!-->×<!--> <!-->10<sup>5</sup>, ceramic/chlorhexidine<!--> <!-->=<!--> <!-->1<!--> <!-->±<!--> <!-->0.2<!--> <!-->×<!--> <!-->10<sup>5</sup>, metal/ZnONPs-mediated aPDT<!--> <!-->=<!--> <!-->1.33<!--> <!-->±<!--> <!-->0.3<!--> <!-->×<!--> <!-->10<sup>5</sup>, and ceramic/ZnONPs-mediated aPDT<!--> <!-->=<!--> <!-->1.2<!--> <!-->±<!--> <!-->0.3<!--> <!-->×<!--> <!-->10<sup>5</sup>). Sodium fluoride varnish and ZnONPs-mediated aPDT showed the highest efficacy in anti-demineralization and significantly improving the enamel surface microhardness compared to the artificial saliva, especially in ceramic bracket groups (524.17<!--> <!-->±<!--> <!-->42.78<!--> <!-->N and 441.00<!--> <!-->±<!--> <!-->29.48<!--> <!-->N, 394.17<!--> <!-->±<!--> <!-->46.83<!--> <!-->N, <em>P</em> <!-->=<!--> <!-->0.000, and <em>P</em> <!-->=<!--> <!-->0.003, respectively).</p></div><div><h3>Conclusion</h3><p>ZnONPs (50<!--> <!-->μg/mL)-mediated aPDT effectively inhibited <em>S. mutans</em> biofilm and promoted anti-demineralization without adverse effects on the physico-mechanical properties of the composite resin. These results suggest the potential of this method in preventing white spot lesions during orthodontic treatment.</p></div>\",\"PeriodicalId\":45449,\"journal\":{\"name\":\"International Orthodontics\",\"volume\":\"22 4\",\"pages\":\"Article 100901\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Orthodontics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1761722724000573\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Orthodontics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1761722724000573","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Assessing the physico-mechanical, anti-bacterial, and anti-demineralization properties of orthodontic resin composite containing different concentrations of photoactivated zinc oxide nanoparticles on Streptococcus mutans biofilm around ceramic and metal orthodontic brackets: An ex vivo study
Background and purpose
The aim of this study was to evaluate the physico-mechanical, anti-bacterial, and anti-demineralization properties of orthodontic resin composite containing photoactivated zinc oxide nanoparticles (ZnONPs) on Streptococcus mutans biofilm around ceramic and metal brackets.
Material and methods
Following the minimum inhibitory concentration (MIC) determination for ZnONPs, shear bond strength (SBS) was tested for composites containing different concentrations of ZnONPs. The chosen concentration was used to evaluate the microleakage, anti-bacterial, and anti-demineralization properties.
Results
Adding 50 μg/mL of ZnONPs to the orthodontic composite did not negatively affect its physico-mechanical properties. ZnONPs (50 μg/mL)-mediated aPDT and 0.2% chlorhexidine significantly (P = 0.000) reduced S. mutans biofilms compared to the phosphate-buffered saline (PBS) groups (metal/PBS = 7.47 ± 0.7 × 106, and ceramic/PBS = 7.47 ± 0.7 × 106), with the lowest colony count observed in these groups (metal/chlorhexidine = 1.06 ± 0.4 × 105, ceramic/chlorhexidine = 1 ± 0.2 × 105, metal/ZnONPs-mediated aPDT = 1.33 ± 0.3 × 105, and ceramic/ZnONPs-mediated aPDT = 1.2 ± 0.3 × 105). Sodium fluoride varnish and ZnONPs-mediated aPDT showed the highest efficacy in anti-demineralization and significantly improving the enamel surface microhardness compared to the artificial saliva, especially in ceramic bracket groups (524.17 ± 42.78 N and 441.00 ± 29.48 N, 394.17 ± 46.83 N, P = 0.000, and P = 0.003, respectively).
Conclusion
ZnONPs (50 μg/mL)-mediated aPDT effectively inhibited S. mutans biofilm and promoted anti-demineralization without adverse effects on the physico-mechanical properties of the composite resin. These results suggest the potential of this method in preventing white spot lesions during orthodontic treatment.
期刊介绍：
Une revue de référence dans le domaine de orthodontie et des disciplines frontières Your reference in dentofacial orthopedics International Orthodontics adresse aux orthodontistes, aux dentistes, aux stomatologistes, aux chirurgiens maxillo-faciaux et aux plasticiens de la face, ainsi quà leurs assistant(e)s. International Orthodontics is addressed to orthodontists, dentists, stomatologists, maxillofacial surgeons and facial plastic surgeons, as well as their assistants.
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