Christian Bogdan, Noor-A-Kasida Islam, David Barinberg, Didier Soulat, Ulrike Schleicher, Baplu Rai
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引用次数: 0
摘要
利什曼原虫是一种通过沙蝇媒介传播的细胞内原生动物，可引起皮肤、粘膜或内脏疾病。它的生长和存活受到 1 型 T 辅助细胞反应的阻碍，其中包括干扰素（IFN）-γ 介导的巨噬细胞活化。利什曼病通过引发有利于寄生虫复制而非杀死寄生虫的免疫细胞和细胞因子反应，部分躲过了宿主的这种防御。原位分析的新方法揭示了免疫控制和微生物逃避的途径受到感染部位的组织环境、微环境因素和新陈代谢的强烈影响，我们将其统称为 "免疫微环境"。了解免疫微环境的组成和影响将有助于开发治疗慢性利什曼病的新策略。
The immunomicrotope of Leishmania control and persistence.
Leishmania is an intracellular protozoan transmitted by sand fly vectors; it causes cutaneous, mucocutaneous, or visceral disease. Its growth and survival are impeded by type 1 T helper cell responses, which entail interferon (IFN)-γ-mediated macrophage activation. Leishmania partially escapes this host defense by triggering immune cell and cytokine responses that favor parasite replication rather than killing. Novel methods for in situ analyses have revealed that the pathways of immune control and microbial evasion are strongly influenced by the tissue context, the micro milieu factors, and the metabolism at the site of infection, which we collectively term the 'immunomicrotope'. Understanding the components and the impact of the immunomicrotope will enable the development of novel strategies for the treatment of chronic leishmaniasis.
期刊介绍：
Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts.
Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.
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