伊朗三级癌症治疗中心十年间小细胞肺癌的流行病学和治疗结果趋势。

Q3 Medicine
Tanaffos Pub Date : 2023-04-01
Sharareh Seifi, Ghazal Fakhrai, Zahra Esfahani-Monfared, Adnan Khosravi, Atefeh Abedini, Babak Salimi, Maryam Seifi, Mahdi Tabarraee, Mahmoud Dehghani Ghorbi
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引用次数: 0

摘要

背景:肺癌是导致癌症死亡的主要原因。在不同的肺癌组织病理学中,小细胞肺癌(SCLC)的侵袭性和致死率最高。本研究分析了伊朗一家三级癌症治疗中心的小细胞肺癌流行病学特征、结果和趋势:回顾性收集了2009-2019年期间在伊朗国家结核病和肺病研究所(NRITLD)经组织学证实的SCLC患者的人口统计学特征和生存结果数据:在334例SCLC患者中,男性患者多于女性,比例为2.5:1,平均诊断年龄为58.36岁。在研究期间,女性患者的性别分布和吸烟状况保持一致,但男性吸烟者明显增加:在我们的系列研究中,SCLC 的发病趋势相对不变,这表明迫切需要进一步研究预防策略,尤其是戒烟、早期检测和新的治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trends in Epidemiology and Outcome of Small Cell Lung Cancer over 10 Years at Tertiary Cancer Care Center in Iran.

Background: Lung cancer is the leading cause of cancer death. Among different lung cancer histopathologies, small cell lung cancer (SCLC) has been known to be the most aggressive and lethal nature. This study analyzed the epidemiological characteristics, outcomes, and trends of SCLC at a tertiary cancer care center in Iran.

Materials and methods: Retrospectively collected demographic characteristics and survival outcome data on histologically proven SCLC patients during 2009-2019 at the National Research Institute of Tuberculosis and Lung Disease (NRITLD) were reviewed.

Results: In a study of 334 SCLC patients, there were more male patients than female, with a ratio of 2.5 to 1, and the mean age at diagnosis was 58.36 years. While gender distribution and smoking status among women remained consistent over the study period, there was a significant increase in male smokers (P<0.001). Female patients were diagnosed at younger age and had a significantly lower proportion of smokers compared to males (P<0.016). The mean and median overall survival were 10.9 and 8.2 months, with one-, two-, and three-year survival rates of 21%, 10%, and 3% respectively. Younger patients and females had significantly higher survival rates. In both uni/multivariate analyses, only age < 58 years and female gender were significantly associated with longer survival.

Conclusion: The relatively unchanged trend of SCLC in our series suggests that further research on prevention strategies especially smoking cessation, early detection, and new treatment options is urgently required.

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Tanaffos
Tanaffos Medicine-Critical Care and Intensive Care Medicine
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