口服与注射：哪种维生素 D 促进剂对低水平维生素 D 最有效？

Q3 Pharmacology, Toxicology and Pharmaceutics

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-08-20 Print Date: 2024-07-26 DOI:10.1515/jbcpp-2024-0018

Neha Agarwal, Pallavi Lohani, Shruti Singh

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引用次数: 0

摘要

目的：维生素 D 对维持骨骼和矿物质平衡至关重要。本研究旨在确定达到最佳维生素 D 水平（≥30 纳克/毫升）的最有效途径，以支持骨骼和矿物质健康：在这项开放标签随机试验中，132 名年龄在 18-60 岁、初始血清维生素 D 水平低于 30 纳克/毫升的参与者被分为三个干预组：每天 800 I.U. 口服片剂组（A 组）、每周 60,000 I.U. 口服袋剂组（B 组）和每月 300,000 I.U. 肌肉注射组（C 组）。研究评估了他们在 6 周和 12 周后血清维生素 D 水平的变化：结果：每月一次肌肉注射（IM）组在六周时的维生素 D 平均水平一直最高，为 38.38（±9.953）（p 结论：每月一次肌肉注射比每月一次肌肉注射更有效：在 6 周和 12 周时，与片剂和袋装维生素 D 相比，每月一次的肌肉注射方式显示出更高的有效性。与其他组别相比，更多的每月 IM 参与者达到了维生素 D 充足水平。

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Oral vs. injected: which vitamin D boost works best for low levels?

Objectives: Vitamin D is essential for maintaining bone and mineral balance. This study aims to identify the most effective route for achieving optimal vitamin D levels (≥30 ng/mL) to support bone and mineral health.

Methods: In this open-label randomized trial, 132 participants aged 18-60 with initial serum vitamin D levels below 30 ng/mL were divided into three intervention groups: daily 800 I.U. oral tablet (Group A), weekly 60,000 I.U. oral sachet (Group B), and monthly 300,000 I.U. intramuscular injection (Group C). The study assessed changes in their serum vitamin D levels at six and 12 weeks.

Results: The monthly intramuscular (IM) group consistently had the highest mean vitamin D levels at six weeks 38.38(±9.953) (p<0.002) and 12 weeks 48.15(±7.71) (p<0.001). Vitamin D insufficiency was reduced to 34.8 % at six weeks (p=0.434) and 6.8 % at 12 weeks (p=0.002). Notably, 100 % of the monthly IM group achieved vitamin D sufficiency at 12 weeks.

Conclusions: The monthly IM route demonstrated superior effectiveness compared to tablets and sachets at both the 6-week and 12-week points. A significantly larger number of monthly IM participants achieved vitamin D sufficiency compared to the other groups.

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来源期刊

Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.