{"title":"口腔疾病中的刺激响应材料:综述。","authors":"Xuguang Gao, Yunyang Li, Jianwen Li, Xi Xiang, Jingwen Wu, Sujuan Zeng","doi":"10.1007/s00784-024-05884-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Oral diseases, such as dental caries, periodontitis, and oral cancers, are highly prevalent worldwide. Many oral diseases are typically associated with bacterial infections or the proliferation of malignant cells, and they are usually located superficially.</p><p><strong>Materials and methods: </strong>Articles were retrieved from PubMed/Medline, Web of Science. All studies focusing on stimuli-responsive materials in oral diseases were included and carefully evaluated.</p><p><strong>Results: </strong>Stimulus-responsive materials are innovative materials that selectively undergo structural changes and trigger drug release based on shifts at the molecular level, such as changes in pH, electric field, magnetic field, or light in the surrounding environment. These changes lead to alterations in the properties of the materials at the macro- or microscopic level. Consequently, stimuli-responsive materials are particularly suitable for treating superficial site diseases and have found extensive applications in antibacterial and anticancer therapies. These characteristics make them convenient and effective for addressing oral diseases.</p><p><strong>Conclusions: </strong>This review aimed to summarize the classification, mechanism of action, and application of stimuli-responsive materials in the treatment of oral diseases, point out the existing limitations, and speculate the prospects for clinical applications.</p><p><strong>Clinical relevance: </strong>Our findings may provide useful information of stimuli-responsive materials in oral diseases for dental clinicians.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Stimuli-responsive materials in oral diseases: a review.\",\"authors\":\"Xuguang Gao, Yunyang Li, Jianwen Li, Xi Xiang, Jingwen Wu, Sujuan Zeng\",\"doi\":\"10.1007/s00784-024-05884-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Oral diseases, such as dental caries, periodontitis, and oral cancers, are highly prevalent worldwide. 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引用次数: 0
摘要
目的:龋齿、牙周炎和口腔癌等口腔疾病在全球范围内非常普遍。许多口腔疾病通常与细菌感染或恶性细胞增殖有关,而且通常位于浅表部位:文章检索自 PubMed/Medline、Web of Science。所有关于刺激响应材料在口腔疾病中的应用的研究均被纳入并进行了仔细评估:刺激响应材料是一种创新材料,可根据分子水平的变化,如周围环境中 pH 值、电场、磁场或光线的变化,选择性地发生结构变化并触发药物释放。这些变化会导致材料在宏观或微观层面的特性发生改变。因此,刺激响应材料特别适用于治疗浅表部位的疾病,并已在抗菌和抗癌疗法中得到广泛应用。这些特点使它们在治疗口腔疾病方面既方便又有效:本综述旨在总结刺激响应材料的分类、作用机制以及在口腔疾病治疗中的应用,指出目前存在的局限性,并展望其临床应用前景:临床相关性:我们的研究结果可为口腔临床医生提供有关刺激反应材料在口腔疾病中应用的有用信息。
Stimuli-responsive materials in oral diseases: a review.
Objectives: Oral diseases, such as dental caries, periodontitis, and oral cancers, are highly prevalent worldwide. Many oral diseases are typically associated with bacterial infections or the proliferation of malignant cells, and they are usually located superficially.
Materials and methods: Articles were retrieved from PubMed/Medline, Web of Science. All studies focusing on stimuli-responsive materials in oral diseases were included and carefully evaluated.
Results: Stimulus-responsive materials are innovative materials that selectively undergo structural changes and trigger drug release based on shifts at the molecular level, such as changes in pH, electric field, magnetic field, or light in the surrounding environment. These changes lead to alterations in the properties of the materials at the macro- or microscopic level. Consequently, stimuli-responsive materials are particularly suitable for treating superficial site diseases and have found extensive applications in antibacterial and anticancer therapies. These characteristics make them convenient and effective for addressing oral diseases.
Conclusions: This review aimed to summarize the classification, mechanism of action, and application of stimuli-responsive materials in the treatment of oral diseases, point out the existing limitations, and speculate the prospects for clinical applications.
Clinical relevance: Our findings may provide useful information of stimuli-responsive materials in oral diseases for dental clinicians.
期刊介绍:
The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.