心外膜和肝脏脂肪对白蛋白尿的影响:一项回顾性研究。

IF 8.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Carolina M Perdomo, Nerea Martin-Calvo, Ana Ezponda, Francisco J Mendoza, Gorka Bastarrika, Nuria Garcia-Fernandez, José I Herrero, Inmaculada Colina, Javier Escalada, Gema Frühbeck
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引用次数: 0

摘要

背景:白蛋白尿被认为是肾功能不全的早期敏感标志物,同时也是一个独立的心血管风险因素。考虑到代谢性肝病、心血管疾病和慢性肾病之间可能存在的关系,我们旨在评估心外膜脂肪组织的存在和脂肪性肝病状态导致白蛋白尿的风险:方法: 我们对 181 名患者进行了一项回顾性长期纵向研究。通过计算机断层扫描评估了心外膜脂肪组织和脂肪肝。结果:中位随访时间为 11.5 年:中位随访 11.2 年后,脂肪肝(HR 3.15;95% CI,1.20-8.26;P = 0.02)和心外膜脂肪组织过多(HR 6.12;95% CI,1.69-22.19;P = 0.在对内脏脂肪组织、性别、年龄、体重状况、2 型糖尿病、糖尿病前期、高甘油三酯血症、高胆固醇血症、动脉高血压和基线时的心血管预防治疗进行调整后,这两种情况都与白蛋白尿风险增加有关。与仅患有脂肪性肝病相比,同时患有这两种疾病的人患白蛋白尿的风险更高(HR 5.91;95% CI 1.15-30.41,p = 0.033)。与内脏脂肪组织的第一个三分位数相比,肝脏脂肪变性和心外膜脂肪组织异常的受试者比例在第二和第三个三分位数中明显较高。我们发现心外膜脂肪与脂肪性肝病之间存在明显的相关性(rho = 0.43 [p 结论:心外膜脂肪与脂肪性肝病之间存在明显的相关性:过多脂肪的识别和管理/减少必须成为慢性肾脏病发展和恶化的一级和二级预防的目标。在日常临床环境中,内脏脂肪含量评估可能是一个适当的目标。此外,心外膜脂肪组织和脂肪肝评估也有助于肾功能障碍的一级预防。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epicardial and liver fat implications in albuminuria: a retrospective study.

Background: Albuminuria is considered an early and sensitive marker of kidney dysfunction, but also an independent cardiovascular risk factor. Considering the possible relationship among metabolic liver disease, cardiovascular disease and chronic kidney disease, we aimed to evaluate the risk of developing albuminuria regarding the presence of epicardial adipose tissue and the steatotic liver disease status.

Methods: A retrospective long-term longitudinal study including 181 patients was carried out. Epicardial adipose tissue and steatotic liver disease were assessed by computed tomography. The presence of albuminuria at follow-up was defined as the outcome.

Results: After a median follow up of 11.2 years, steatotic liver disease (HR 3.15; 95% CI, 1.20-8.26; p = 0.02) and excess amount of epicardial adipose tissue (HR 6.12; 95% CI, 1.69-22.19; p = 0.006) were associated with an increased risk of albuminuria after adjustment for visceral adipose tissue, sex, age, weight status, type 2 diabetes, prediabetes, hypertriglyceridemia, hypercholesterolemia, arterial hypertension, and cardiovascular prevention treatment at baseline. The presence of both conditions was associated with a higher risk of developing albuminuria compared to having steatotic liver disease alone (HR 5.91; 95% CI 1.15-30.41, p = 0.033). Compared with the first tertile of visceral adipose tissue, the proportion of subjects with liver steatosis and abnormal epicardial adipose tissue was significantly higher in the second and third tertile. We found a significant correlation between epicardial fat and steatotic liver disease (rho = 0.43 [p < 0.001]).

Conclusions: Identification and management/decrease of excess adiposity must be a target in the primary and secondary prevention of chronic kidney disease development and progression. Visceral adiposity assessment may be an adequate target in the daily clinical setting. Moreover, epicardial adipose tissue and steatotic liver disease assessment may aid in the primary prevention of renal dysfunction.

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来源期刊
Cardiovascular Diabetology
Cardiovascular Diabetology 医学-内分泌学与代谢
CiteScore
12.30
自引率
15.10%
发文量
240
审稿时长
1 months
期刊介绍: Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.
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