解密遗传景观:长乐鹅基因组特征的洞察力。

IF 3.5 2区 生物学 Q1 EVOLUTIONARY BIOLOGY
Hao Chen, Yan Wu, Yihao Zhu, Keyi Luo, Sumei Zheng, Hongbo Tang, Rui Xuan, Yuxuan Huang, Jiawei Li, Rui Xiong, Xinyan Fang, Lei Wang, Yujie Gong, Junjie Miao, Jing Zhou, Hongli Tan, Yanan Wang, Liping Wu, Jing Ouyang, Min Huang, Xueming Yan
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引用次数: 0

摘要

长乐鹅(CLG)是中国的本土品种,因其适应性强、生长迅速和肉质上乘而备受赞誉。尽管长乐鹅具有农业价值,但对其基因组属性的研究却很少。我们的研究对 303 只中国鹅和其他五个中国品种的鹅进行了全基因组重测序,发现了不同的遗传多样性指标。我们发现了从兴国灰鹅到中国鹅的重要迁移事件,以及它们之间的少量基因流动。我们通过选择性扫描分析确定了与中国鹅独特性状相关的基因组区域。CLG的近交系数升高,同时杂合度和稀有单核苷酸多态性(RSNPs)降低,表明其遗传多样性变窄。研究发现了与繁殖、肉质和生长相关的基因组区域,其中 GATA3 基因在肉质方面表现出强烈的选择信号。Sloc2a1基因中的一个非同义突变与CLG的繁殖性状有关,其等位基因频率存在显著差异。CD82、CDH8和PRKAB1在生长发育中的作用,以及FABP4、FAF1、ESR1和AKAP12在繁殖中的作用都得到了强调。此外,Cdkal1 和 Mfsd14a 可能会影响肉质。这项全面的遗传分析证明了CLG独特的遗传组成,为其保护和知情育种策略提供了依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Deciphering the Genetic Landscape: Insights Into the Genomic Signatures of Changle Goose

Deciphering the Genetic Landscape: Insights Into the Genomic Signatures of Changle Goose

The Changle goose (CLG), a Chinese indigenous breed, is celebrated for its adaptability, rapid growth, and premium meat quality. Despite its agricultural value, the exploration of its genomic attributes has been scant. Our study entailed whole-genome resequencing of 303 geese across CLG and five other Chinese breeds, revealing distinct genetic diversity metrics. We discovered significant migration events from Xingguo gray goose to CLG and minor gene flow between them. We identified genomic regions through selective sweep analysis, correlating with CLG's unique traits. An elevated inbreeding coefficient in CLG, alongside reduced heterozygosity and rare single nucleotide polymorphisms (RSNPs), suggests a narrowed genetic diversity. Genomic regions related to reproduction, meat quality, and growth were identified, with the GATA3 gene showing strong selection signals for meat quality. A non-synonymous mutation in the Sloc2a1 gene, which is associated with reproductive traits in the CLG, exhibited significant differences in allelic frequency. The roles of CD82, CDH8, and PRKAB1 in growth and development, alongside FABP4, FAF1, ESR1, and AKAP12 in reproduction, were highlighted. Additionally, Cdkal1 and Mfsd14a may influence meat quality. This comprehensive genetic analysis underpins the unique genetic makeup of CLG, providing a basis for its conservation and informed breeding strategies.

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来源期刊
Evolutionary Applications
Evolutionary Applications 生物-进化生物学
CiteScore
8.50
自引率
7.30%
发文量
175
审稿时长
6 months
期刊介绍: Evolutionary Applications is a fully peer reviewed open access journal. It publishes papers that utilize concepts from evolutionary biology to address biological questions of health, social and economic relevance. Papers are expected to employ evolutionary concepts or methods to make contributions to areas such as (but not limited to): medicine, agriculture, forestry, exploitation and management (fisheries and wildlife), aquaculture, conservation biology, environmental sciences (including climate change and invasion biology), microbiology, and toxicology. All taxonomic groups are covered from microbes, fungi, plants and animals. In order to better serve the community, we also now strongly encourage submissions of papers making use of modern molecular and genetic methods (population and functional genomics, transcriptomics, proteomics, epigenetics, quantitative genetics, association and linkage mapping) to address important questions in any of these disciplines and in an applied evolutionary framework. Theoretical, empirical, synthesis or perspective papers are welcome.
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