在单分子水平上观察染色质上表观遗传调节因子的动态变化

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-08-22 DOI:10.1038/s41594-024-01374-8

引用次数: 0

摘要

甲基-CpG结合蛋白2（MeCP2）是神经元基因表达的主要调控因子，其基因突变会导致神经发育障碍性疾病Rett综合征。单分子实验能够直接观察到MeCP2在DNA上的动态变化，从而揭示特定染色质环境是如何调整MeCP2功能的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Dynamics of an epigenetic regulator on chromatin observed at the single-molecule level

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Dynamics of an epigenetic regulator on chromatin observed at the single-molecule level

Methyl-CpG-binding protein 2 (MeCP2) is a master regulator of neuronal gene expression, and its genetic mutations cause the neurodevelopmental disorder Rett syndrome. Single-molecule experiments have enabled the direct visualization of the dynamics of MeCP2 on DNA, shedding light on how the specific chromatin context tunes MeCP2 function.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.