Diane N. Sayah OD, PhD , Denise Descovich MD , Santiago Costantino PhD , Mark R. Lesk MD, MSc
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Ocular rigidity was measured using an invasive procedure as well as using a validated optical method. Correlations between ΔV and OR were assessed in subjects with healthy eyes, eyes with glaucoma, or eyes with exudative retinal disease.</p></div><div><h3>Main Outcome Measures</h3><p>Ocular rigidity and pulsatile ocular volume change.</p></div><div><h3>Results</h3><p>In 18 eyes where OR was obtained invasively and ΔV was obtained noninvasively, a significant correlation was found between ΔV and OR (r<sub>s</sub> = −0.664, <em>P</em> = 0.003). Similarly, a strong inverse correlation was found between the noninvasive measurements of both ΔV and OR (r<sub>s</sub> = −0.748, <em>P</em> < 0.001) in a large cohort and maintained its significance across diagnostic groups (a more compliant eye is associated with greater ΔV). No correlation was found between ΔV and age, blood pressure, intraocular pressure, axial length, or diagnosis (<em>P</em> ≥ 0.05). Mean ΔV was 7.3 ± 3.4 μL for all groups combined with a range of 3.0 to 20.8 μL.</p></div><div><h3>Conclusions</h3><p>These results suggest an association between the biomechanics of the corneoscleral shell and pulsatile ocular blood flow, which may indicate that a more rigid eye exerts more resistance to pulsatile choroidal expansion. This highlights the dynamic nature of both blood flow and biomechanics in the eye, as well as how they may interact, leading to a greater understanding of the pathophysiology of ocular disease.</p></div><div><h3>Financial Disclosures</h3><p>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p></div>","PeriodicalId":74363,"journal":{"name":"Ophthalmology science","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266691452400112X/pdfft?md5=ddd401d8b394fedad1dc8122bed5d1a8&pid=1-s2.0-S266691452400112X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The Association between the Pulsatile Choroidal Volume Change and Ocular Rigidity\",\"authors\":\"Diane N. Sayah OD, PhD , Denise Descovich MD , Santiago Costantino PhD , Mark R. 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Correlations between ΔV and OR were assessed in subjects with healthy eyes, eyes with glaucoma, or eyes with exudative retinal disease.</p></div><div><h3>Main Outcome Measures</h3><p>Ocular rigidity and pulsatile ocular volume change.</p></div><div><h3>Results</h3><p>In 18 eyes where OR was obtained invasively and ΔV was obtained noninvasively, a significant correlation was found between ΔV and OR (r<sub>s</sub> = −0.664, <em>P</em> = 0.003). Similarly, a strong inverse correlation was found between the noninvasive measurements of both ΔV and OR (r<sub>s</sub> = −0.748, <em>P</em> < 0.001) in a large cohort and maintained its significance across diagnostic groups (a more compliant eye is associated with greater ΔV). No correlation was found between ΔV and age, blood pressure, intraocular pressure, axial length, or diagnosis (<em>P</em> ≥ 0.05). 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引用次数: 0
摘要
目的评估脉动脉络膜体积变化（ΔV）与眼球刚度（OR）之间的关系，眼球刚度是眼球的重要生物力学特性。其中，18 只眼睛（18 名参与者）患有渗出性视网膜疾病，217 只眼睛（199 名参与者）患有开角型青光眼（39.2%）、可疑椎间盘（12.4%）、眼压过高（14.3%）或健康眼睛（34.1%）。方法使用动态 OCT 测量脉动脉络膜体积变化，该技术可检测心动周期中脉络膜厚度的变化。眼球僵硬度采用侵入性程序和有效光学方法进行测量。在健康眼、青光眼眼或渗出性视网膜疾病眼的受试者中评估了ΔV 和 OR 之间的相关性。结果在 18 只用有创方法测量 OR 而用无创方法测量ΔV 的眼睛中，发现ΔV 和 OR 之间存在显著相关性（rs = -0.664，P = 0.003）。同样，在一个大型队列中，ΔV 和 OR 的无创测量值之间也发现了很强的反相关性（rs = -0.748，P = 0.001），并且在不同诊断组别中都保持着显著性（顺应性更强的眼睛与更大的ΔV 相关）。ΔV与年龄、血压、眼压、眼轴长度或诊断之间没有相关性（P≥0.05）。结论：这些结果表明角巩膜壳的生物力学与眼部搏动性血流之间存在关联，这可能表明眼球越僵硬，对搏动性脉络膜扩张的阻力越大。这凸显了眼部血流和生物力学的动态性质，以及它们之间的相互作用，从而加深了对眼部疾病病理生理学的理解。
The Association between the Pulsatile Choroidal Volume Change and Ocular Rigidity
Purpose
To assess the relationship between the pulsatile choroidal volume change (ΔV) and ocular rigidity (OR), an important biomechanical property of the eye.
Design
This is a prospective cross-sectional study.
Subjects
Two hundred seventeen participants (235 eyes) were included in this study. Of those, 18 eyes (18 participants) had exudative retinal disease, and 217 eyes (199 participants) had open-angle glaucoma (39.2%), suspect discs (12.4%), ocular hypertension (14.3%), or healthy eyes (34.1%).
Methods
Pulsatile choroidal volume change was measured using dynamic OCT, which detects the change in choroidal thickness during the cardiac cycle. Ocular rigidity was measured using an invasive procedure as well as using a validated optical method. Correlations between ΔV and OR were assessed in subjects with healthy eyes, eyes with glaucoma, or eyes with exudative retinal disease.
Main Outcome Measures
Ocular rigidity and pulsatile ocular volume change.
Results
In 18 eyes where OR was obtained invasively and ΔV was obtained noninvasively, a significant correlation was found between ΔV and OR (rs = −0.664, P = 0.003). Similarly, a strong inverse correlation was found between the noninvasive measurements of both ΔV and OR (rs = −0.748, P < 0.001) in a large cohort and maintained its significance across diagnostic groups (a more compliant eye is associated with greater ΔV). No correlation was found between ΔV and age, blood pressure, intraocular pressure, axial length, or diagnosis (P ≥ 0.05). Mean ΔV was 7.3 ± 3.4 μL for all groups combined with a range of 3.0 to 20.8 μL.
Conclusions
These results suggest an association between the biomechanics of the corneoscleral shell and pulsatile ocular blood flow, which may indicate that a more rigid eye exerts more resistance to pulsatile choroidal expansion. This highlights the dynamic nature of both blood flow and biomechanics in the eye, as well as how they may interact, leading to a greater understanding of the pathophysiology of ocular disease.
Financial Disclosures
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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