Irmak Icen Taskin, Sevim Gurbuz, Mehmet Sait Icen, Dilek Cam Derin, Fatih Mehmet Findik, Engin Deveci
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引用次数: 0
摘要
目的：胎盘早剥谱（PAS胎盘早剥谱（PAS）是指胎盘不同程度地附着在子宫壁上。然而，有关 PAS 潜在分子机制的研究却非常有限。Sirtuins 1（SIRT1）通过控制滋养层细胞的侵入和螺旋动脉的重塑与胎盘的发育有关。我们旨在确定 SIRT1 在 PAS 患者胎盘、母体和脐带血清中的表达水平：本研究共纳入了 30 名对照组患者、20 名前置胎盘组患者和 30 名 PAS 组患者。胎盘中SIRT1的表达水平通过Western印迹和免疫组化法测定。用酶联免疫吸附法测定母体和脐带血中 SIRT1 的血清水平：结果：PAS 胎盘中的 SIRT1 水平明显较低。结论：SIRT1 在 PAS 胎盘中可能起着重要作用：结论：SIRT1可能在PAS的发病机制中扮演重要角色。
Expression of sirtuins 1 in placenta, umbilical cord, and maternal serum of patients diagnosed with placenta accreta spectrum.
Objective: Placenta accreta spectrum (PAS) is defined as the attachment of the placenta to the uterine wall in varying degrees. However, the studies have explored that the underlying molecular mechanisms of the PAS are very limited. Sirtuins 1 (SIRT1) is associated with placental development by controlling trophoblast cell invasion and remodeling of spiral arteries. We aimed to determine the expression level of SIRT1 in placentas, and maternal and umbilical cord serum of patients with PAS.
Methods: In total, 30 individuals in control, 20 patients in the placenta previa group, and 30 patients in the PAS group were included in this study. The expression levels of SIRT1 in the placentas were determined by Western blot and immunohistochemistry. Serum levels of SIRT1 in maternal and umbilical cord blood were determined by ELISA.
Results: SIRT1 was significantly lower in placentas of the PAS. However, maternal and umbilical cord serum samples were not significantly different between groups.
Conclusion: SIRT1 may play an important role in the pathogenesis of the PAS.
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