从太空人类干细胞研究中发现与推动地球细胞疗法有关的发现。

IF 4.4 1区物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES

npj Microgravity Pub Date : 2024-08-21 DOI:10.1038/s41526-024-00425-0

Fay Ghani, Abba C Zubair

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引用次数: 0

摘要

在太空中进行的干细胞研究为了解干细胞在微重力环境下的特性和行为（包括细胞增殖、分化和再生能力）提供了基本见解。不过，这项研究还有更广泛的科学价值，包括将太空干细胞研究转化为临床应用的潜力。在此，我们将介绍在太空中进行的不同研究的重要发现，展示人类干细胞的潜在用途以及细胞疗法的局限性。要将研究成果转化为临床应用，还需要充分了解太空微重力对支持干细胞功能扩展和/或增强的潜在影响。

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Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth.

Stem cell research performed in space has provided fundamental insights into stem cell properties and behavior in microgravity including cell proliferation, differentiation, and regeneration capabilities. However, there is broader scientific value to this research including potential translation of stem cell research in space to clinical applications. Here, we present important discoveries from different studies performed in space demonstrating the potential use of human stem cells as well as the limitations in cellular therapeutics. A full understanding of the effects of microgravity in space on potentially supporting the expansion and/or enhancement of stem cell function is required to translate the findings into clinics.

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来源期刊

npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)

CiteScore

7.30

自引率

7.80%

发文量

审稿时长

9 weeks

期刊介绍： A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.