吲哚菁绿与肝胆外科:当前文献综述。

IF 1.1 4区 医学 Q3 SURGERY
Laura Fortuna, Simone Buccianti, Matteo Risaliti, Francesco Matarazzo, Carlotta Agostini, Maria Novella Ringressi, Antonio Taddei, Ilenia Bartolini, Gian Luca Grazi
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引用次数: 0

摘要

吲哚菁绿(ICG)是一种惰性多肽,几乎能完全与高分子量血浆蛋白结合;它能被肝细胞清除并直接排入胆汁,半衰期约为 3-5 分钟。需要特定的系统才能看到荧光图像。据报道,这种染料已用于不同的外科专科,在肝胆外科的应用也在不断扩大。它首先用于评估术前肝功能,术中和术后动态检查肝脏活动也有报道,并被纳入围手术期方案中,可进行有针对性的治疗分配。静脉注射(IV)或胆囊注射可以减轻胆囊切除术的难度。通过静脉注射 ICG 可以加强胆漏检测。尽管结果存在一些差异,但使用ICG划定切除范围和增强肿瘤可视性都能改善短期和长期预后。尽管缺乏有力的证据,这一工具仍无法应用于临床实践,但它在肝脏手术中蕴藏着巨大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Indocyanine Green and Hepatobiliary Surgery: An Overview of the Current Literature.

Indocyanine green (ICG) is an inert polypeptide that almost totally binds to high molecular weight plasma proteins; it is cleared by the hepatocytes and directly excreted into the bile with a half-life of about 3-5 minutes. Specific systems are required to see fluorescent images. The use of this dye has been reported in different surgical specialties, and the applications in hepatobiliary surgery are widening. Being firstly used to evaluate the preoperative liver function, intra- and postoperative dynamic checking of hepatic activity has been reported and integrated within perioperative protocols allowing a tailored treatment allocation. Intravenous injection (IV) or injection into the gallbladder can ease difficult cholecystectomy. Biliary leakage detection could be enhanced by IV ICG injection. Although with some contrasting results, the use of ICG for both delineating the limits of the resection and tumor-enhanced visualization was demonstrated to improve short- and long-term outcomes. Although the lack of strong evidence still precludes the introduction of this tool in clinical practice, it harbors great potential in liver surgery.

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来源期刊
CiteScore
2.90
自引率
0.00%
发文量
163
审稿时长
3 months
期刊介绍: Journal of Laparoendoscopic & Advanced Surgical Techniques (JLAST) is the leading international peer-reviewed journal for practicing surgeons who want to keep up with the latest thinking and advanced surgical technologies in laparoscopy, endoscopy, NOTES, and robotics. The Journal is ideally suited to surgeons who are early adopters of new technology and techniques. Recognizing that many new technologies and techniques have significant overlap with several surgical specialties, JLAST is the first journal to focus on these topics both in general and pediatric surgery, and includes other surgical subspecialties such as: urology, gynecologic surgery, thoracic surgery, and more.
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