{"title":"Stereuins A-F：Stereum hirsutum HFG27 中具有抗菌和神经营养活性的异戊烯苯同系物。","authors":"","doi":"10.1016/j.phytochem.2024.114253","DOIUrl":null,"url":null,"abstract":"<div><p>Cultivation and extraction of the fungus <em>Stereum hirsutum</em> (Willd.) Pers. yielded 12 isopentenyl benzene derivatives, including six previously undescribed derivatives, named stereuins A–F. Their structures were established based on NMR and mass spectroscopy analyses, supplemented by comparison with previously reported data. Stereuins A–C are unique benzoate derivatives containing fatty acid subunits. Stereuins D and E feature a valylene group and a 6/6/6 ring system. <em>In vitro</em>, stereuin A significantly promoted neurite outgrowth. Several compounds exhibited antibacterial activity against <em>Staphylococcus aureus</em>. Stereuin F has an IC<sub>50</sub> value of 5.2 μg/mL against <em>S. aureus</em>, comparable to the positive control, penicillin G sodium (1.4 μg/mL).</p></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Stereuins A–F: Isopentenyl benzene congeners with antibacterial and neurotrophic activities from Stereum hirsutum HFG27\",\"authors\":\"\",\"doi\":\"10.1016/j.phytochem.2024.114253\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cultivation and extraction of the fungus <em>Stereum hirsutum</em> (Willd.) Pers. yielded 12 isopentenyl benzene derivatives, including six previously undescribed derivatives, named stereuins A–F. Their structures were established based on NMR and mass spectroscopy analyses, supplemented by comparison with previously reported data. Stereuins A–C are unique benzoate derivatives containing fatty acid subunits. Stereuins D and E feature a valylene group and a 6/6/6 ring system. <em>In vitro</em>, stereuin A significantly promoted neurite outgrowth. Several compounds exhibited antibacterial activity against <em>Staphylococcus aureus</em>. Stereuin F has an IC<sub>50</sub> value of 5.2 μg/mL against <em>S. aureus</em>, comparable to the positive control, penicillin G sodium (1.4 μg/mL).</p></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031942224002905\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942224002905","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
对真菌 Stereum hirsutum (Willd.) Pers.进行培养和提取，获得了 12 种异戊烯基苯衍生物，其中包括 6 种以前未曾描述过的衍生物，命名为立体素 A-F。这些衍生物的结构是根据核磁共振和质谱分析确定的，并与以前报道的数据进行了比较。立体素 A-C 是含有脂肪酸亚基的独特苯甲酸酯衍生物。立体素 D 和 E 具有一个缬烯基和一个 6/6/6 环系统。在体外，立体素 A 能显著促进神经元的生长。一些化合物对金黄色葡萄球菌具有抗菌活性。立体素 F 对金黄色葡萄球菌的 IC50 值为 5.2 μg/mL，与阳性对照青霉素 G 钠（1.4 μg/mL）相当。
Stereuins A–F: Isopentenyl benzene congeners with antibacterial and neurotrophic activities from Stereum hirsutum HFG27
Cultivation and extraction of the fungus Stereum hirsutum (Willd.) Pers. yielded 12 isopentenyl benzene derivatives, including six previously undescribed derivatives, named stereuins A–F. Their structures were established based on NMR and mass spectroscopy analyses, supplemented by comparison with previously reported data. Stereuins A–C are unique benzoate derivatives containing fatty acid subunits. Stereuins D and E feature a valylene group and a 6/6/6 ring system. In vitro, stereuin A significantly promoted neurite outgrowth. Several compounds exhibited antibacterial activity against Staphylococcus aureus. Stereuin F has an IC50 value of 5.2 μg/mL against S. aureus, comparable to the positive control, penicillin G sodium (1.4 μg/mL).
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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