尿道后瓣膜患儿的长期肾脏预后:基于人群的队列研究。

IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Cal H Robinson, Mandy Rickard, Nivethika Jeyakumar, Graham Smith, Juliane Richter, Tim Van Mieghem, Joana Dos Santos, Rahul Chanchlani, Armando J Lorenzo
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引用次数: 0

摘要

背景:后尿道瓣膜是导致男婴下尿路梗阻的最常见原因(1/4000 活产婴儿)。后尿道瓣膜对肾脏的长期影响仍不确定。我们旨在确定后尿道瓣膜患儿成年后发生重大肾脏不良事件(MAKE)的时间变化风险:方法:一项基于人群的回顾性队列研究,研究对象为所有男性(结果:727 名患有后尿道瓣膜的儿童被纳入研究:我们纳入了 727 名患有后尿道瓣膜的儿童、855 名肾盂成形术比较者和 1,013,052 名普通人群比较者。总体随访时间中位数为 16.6 年(Q1-3 8.6-24.5)。在整个随访过程中,32%的后尿道瓣膜患儿发生了MAKE,而普通人群和肾盂成形术比较者中分别为1%和6%。与普通人群相比,他们患 MAKE 的调整危险比为 36.6(95%CI 31.6-42.4)。在后尿道瓣膜确诊后的头 5 年中,患 MAKE 的风险有所下降,但在超过 30 年的随访中,其风险仍然较高。与普通人群或肾盂成形术比较者相比,患有后尿道瓣膜的儿童患死亡、慢性肾病、长期肾脏替代治疗、高血压和急性肾损伤的风险也更高:结论:患有后尿道瓣膜的儿童成年后长期肾功能不良的风险较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-Term Kidney Outcomes in Children with Posterior Urethral Valves: A Population-Based Cohort Study.
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来源期刊
Journal of The American Society of Nephrology
Journal of The American Society of Nephrology 医学-泌尿学与肾脏学
CiteScore
22.40
自引率
2.90%
发文量
492
审稿时长
3-8 weeks
期刊介绍: The Journal of the American Society of Nephrology (JASN) stands as the preeminent kidney journal globally, offering an exceptional synthesis of cutting-edge basic research, clinical epidemiology, meta-analysis, and relevant editorial content. Representing a comprehensive resource, JASN encompasses clinical research, editorials distilling key findings, perspectives, and timely reviews. Editorials are skillfully crafted to elucidate the essential insights of the parent article, while JASN actively encourages the submission of Letters to the Editor discussing recently published articles. The reviews featured in JASN are consistently erudite and comprehensive, providing thorough coverage of respective fields. Since its inception in July 1990, JASN has been a monthly publication. JASN publishes original research reports and editorial content across a spectrum of basic and clinical science relevant to the broad discipline of nephrology. Topics covered include renal cell biology, developmental biology of the kidney, genetics of kidney disease, cell and transport physiology, hemodynamics and vascular regulation, mechanisms of blood pressure regulation, renal immunology, kidney pathology, pathophysiology of kidney diseases, nephrolithiasis, clinical nephrology (including dialysis and transplantation), and hypertension. Furthermore, articles addressing healthcare policy and care delivery issues relevant to nephrology are warmly welcomed.
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