HLA-DRB1 等位基因与乙型肝炎表面抗原和 e 抗原抗体状态的关系。

IF 6.8 3区医学 Q1 VIROLOGY

Journal of Medical Virology Pub Date : 2024-08-21 DOI:10.1002/jmv.29867

Xinze Li, Qiaomiao Zhou, Zhe Lu, Renliang Huang, Dan Lin, Jing Xu, Xinhua Yu, Xuexia Li

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引用次数: 0

摘要

HLA II类分子向CD4+ T细胞呈递抗原是产生乙型肝炎抗原抗体的必要步骤。在这项研究中，我们调查了 HLA-DRB1 基因与乙肝表面抗原和 e 抗原抗体状态之间的关联。结果显示，抗 HBsAg 状态与 HLA-DRB1*04:03 （OR = 4.11，95% CI = 1.50-10.84，p = 0.005，Padj. = 0.05）以及 HLA-DRB1*15:01 （OR = 1.74，95% CI = 1.20-2.50，p = 0.002，Padj. = 0.045）之间存在明显关联。MHC II 结合预测和硅对接表明，HBsAg 肽与这两种 HLA-DRB1 分子有很强的结合亲和力。相反，抗 HBeAg 状态与 HLA-DRB1*14:54 呈反比关系（OR = 0.34，95% CI = 0.18-0.64，P = 0.001，Padj. = 0.011），硅学分析显示 HBeAg 肽与 HLA-DRB1*14:54 的结合亲和力较弱。总之，这些研究结果支持 HLA-DRB1 参与抗 HBV 感染的体液免疫。

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Association of HLA-DRB1 alleles with status of antibodies to hepatitis B surface and e antigen

Antigen presentation by HLA class II molecules to CD4⁺ T cells is an essential step for generating antibodies to hepatitis B antigens. In this study, we investigated the association between the HLA-DRB1 gene and the status of antibodies to hepatitis B surface and e antigens. Our results revealed a significant association between the status of anti-HBsAg and HLA-DRB1*04:03 (OR = 4.11, 95% CI = 1.50–10.84, p = 0.005, P_adj. = 0.05) as well as HLA-DRB1*15:01 (OR = 1.74, 95% CI = 1.20–2.50, p = 0.002, P_adj. = 0.045). MHC II binding predictions and in silico docking demonstrated strong binding affinity of HBsAg peptides to these two HLA-DRB1 molecules. Conversely, the status of anti-HBeAg was inversely associated with HLA-DRB1*14:54 (OR = 0.34, 95% CI = 0.18–0.64, p = 0.001, P_adj. = 0.011), and in silico analysis revealed weak binding affinity of HBeAg peptides to HLA-DRB1*14:54. In conclusion, these findings support the involvement of HLA-DRB1 in humoral immunity against HBV infection.

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来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.