幽门螺旋杆菌中由 cag 致病岛编码的 IV 型分泌系统各组成部分的作用。

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Future microbiology Pub Date : 2024-08-22 DOI:10.1080/17460913.2024.2383514

Lingzhu Gou, Xiaoping Yang, Jianwei Yun, Zenghui Ma, Xiaofeng Zheng, Hongwei Du, Dekui Zhang

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引用次数: 0

摘要

幽门螺杆菌（H. pylori）细胞毒素相关基因致病性岛（cagPAI）编码 31 个基因，这些基因组装了 cag IV 型分泌系统（T4SS）装置，其中包括外膜核心复合体、周质环、内膜复合体和菌毛等结构。这些蛋白质相互作用，将 CagA 注入宿主胃上皮细胞。此外，幽门螺杆菌还有一些独特的功能，可以帮助其干扰宿主细胞通路、调节免疫反应并在宿主体内长期定植。然而，其中一些蛋白质的功能仍不清楚。本综述总结了目前已知的这些辅助成分的结构和功能，并讨论了它们在幽门螺杆菌发病机制中的作用。

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Roles of the components of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori.

The Helicobacter pylori (H. pylori) cytotoxin-associated gene pathogenicity island (cagPAI) encodes 31 genes that assemble the cag type IV secretion system (T4SS) apparatus, which includes structures such as the outer membrane core complex, periplasmic ring, inner membrane complex and bacterial hairs. These proteins interact with each other to inject CagA into the host gastric epithelium. There are also individual unique functions that help H. pylori interfere with host cellular pathways, modulate the immune response and colonize the host for a long time. However, the functions of some of the proteins remain unclear. This review summarizes what is known about the structure and function of these auxiliary components and discusses their role in H. pylori pathogenesis.

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来源期刊

Future microbiology 生物-微生物学

CiteScore

4.90

自引率

3.20%

发文量

134

审稿时长

6-12 weeks

期刊介绍： Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.