MYC-MAF-SAGA 轴驱动多发性骨髓瘤中致癌基因的表达。

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2024-09-19 DOI:10.1101/gad.352186.124

Hongkuan Wang, Hong Wen, Xiaobing Shi

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引用次数: 0

摘要

SAGA 复合物是一种进化保守的组蛋白乙酰转移酶复合物和转录辅激活因子，对发育和疾病至关重要。SAGA 的失调与包括癌症在内的多种人类疾病有关。在本期《基因与发育》（Genes & Development）杂志上，Chen 等人（doi/10.1101/gad.351789.124）揭示了 SAGA 在多发性骨髓瘤中的关键作用，其中 SAGA 的 ADA2B 成分是表达 mTORC1 通路基因以及 MYC、E2F 和 MAF（肌肉神经纤维肉瘤）转录因子靶点所必需的。SAGA 与 MYC 和 MAF 合作，维持对多发性骨髓瘤存活至关重要的致癌基因表达程序，因此可能成为未来癌症疗法的治疗靶点。

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The MYC-MAF-SAGA axis drives oncogenic gene expression in multiple myeloma.

The SAGA complex is an evolutionarily conserved histone acetyltransferase complex and transcription coactivator essential for development and disease. Dysregulation of SAGA is implicated in various human diseases, including cancer. In this issue of Genes & Development, Chen et al. (doi:10.1101/gad.351789.124) uncover a critical role for SAGA in multiple myeloma wherein SAGA's ADA2B component is required for the expression of mTORC1 pathway genes and targets of the MYC, E2F, and MAF (musculoaponeurotic fibrosarcoma) transcription factors. SAGA cooperates with MYC and MAF to sustain oncogenic gene expression programs vital for multiple myeloma survival and thus may serve as a therapeutic target for future cancer therapies.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).