孕妇接触邻苯二甲酸盐与睡眠质量之间的关系:韩国儿童环境健康研究重复评估接触情况的结果。

IF 3.3 Q2 ENVIRONMENTAL SCIENCES
Environmental Epidemiology Pub Date : 2024-08-20 eCollection Date: 2024-10-01 DOI:10.1097/EE9.0000000000000329
Dirga Kumar Lamichhane, Eunhee Ha, Amanda V Bakian, Yun-Chul Hong, Dong-Wook Lee, Myung-Sook Park, Sanghwan Song, Suejin Kim, Hyunju Park, Woo Jin Kim, Jisuk Bae, Hwan-Cheol Kim
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引用次数: 0

摘要

背景:有越来越多的证据表明,环境毒物与睡眠质量有关;然而,这些关联在孕期仍不明确。我们研究了重复测量孕早期和孕晚期尿液中邻苯二甲酸盐与孕妇睡眠质量的多种指标之间的关系:研究对象包括韩国儿童环境健康研究中的 2324 名孕妇。我们分析了在孕期两个时间点采集的点滴尿样,以检测八种邻苯二甲酸酯代谢物的暴露生物标记物。我们研究了四种邻苯二甲酸盐(所有邻苯二甲酸盐、∑Ph邻苯二甲酸酯:∑Phthalates;邻苯二甲酸二(2-乙基己酯):∑DEHP;塑料来源的邻苯二甲酸酯:∑Phthalates;塑料来源的邻苯二甲酸二(2-乙基己酯):∑Phthalates;塑料来源的邻苯二甲酸二(2-乙基己酯):∑Phthalates:∑塑料;以及抗雄激素邻苯二甲酸盐:这些模型对年龄、体重指数、教育程度、胎龄、收入、体力活动、吸烟、职业、慢性病、抑郁和尿可替宁水平进行了调整:结果:多种单个邻苯二甲酸盐和邻苯二甲酸盐混合物(包括∑塑料、∑DEHP、∑AA 和∑邻苯二甲酸盐)的综合测量值与睡眠效率降低有关。例如,∑AA 每增加 1 个对数,睡眠效率就会降低 1.37%(95% 置信区间 [CI] = -2.41,-0.32)。∑AA和∑邻苯二甲酸盐还与睡眠时间缩短和睡眠潜伏期延长有关。尿液中可替宁的水平不同,邻苯二甲酸盐测量值与睡眠效率之间的关系也不同(亚组差异 P < 0.05):研究结果表明,妊娠期间较高的邻苯二甲酸盐暴露量可能与较低的睡眠效率、较短的睡眠持续时间和较长的睡眠潜伏期有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between phthalate exposure and sleep quality in pregnant women: Results from the Korean Children's Environmental Health Study with repeated assessment of exposure.

Background: Evidence linking environmental toxicants to sleep quality is growing; however, these associations during pregnancy remain unclear. We examined the associations of repeated measures of urinary phthalates in early and late pregnancy with multiple markers of sleep quality among pregnant women.

Methods: The study population included 2324 pregnant women from the Korean Children's Environmental Health Study. We analyzed spot urine samples collected at two time points during pregnancy for exposure biomarkers of eight phthalate metabolites. We investigated associations between four summary phthalates (all phthalates: ∑Phthalates; di-(2-ethylhexyl) phthalate: ∑DEHP; phthalates from plastic sources: ∑Plastic; and antiandrogenic phthalates: ∑AA) and eight individual phthalates and self-reported sleep measures using generalized ordinal logistic regression and generalized estimating equations models that accounted for repeated exposure measurements. The models were adjusted for age, body mass index, education, gestational age, income, physical activity, smoking, occupation, chronic diseases, depression, and urinary cotinine levels.

Results: Multiple individual phthalates and summary measures of phthalate mixtures, including ∑Plastic, ∑DEHP, ∑AA, and ∑Phthalates, were associated with lower sleep efficiency. To illustrate, every 1-unit log increase in ∑AA was associated with a reduction of sleep efficiency by 1.37 % (95% confidence interval [CI] = -2.41, -0.32). ∑AA and ∑Phthalates were also associated with shorter sleep duration and longer sleep latency. Associations between summary phthalate measures and sleep efficiency differed by urinary cotinine levels (P for subgroup difference < 0.05).

Conclusions: Findings suggest that higher phthalate exposure may be related to lower sleep efficiency, shorter sleep duration, and prolonged sleep latency during pregnancy.

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来源期刊
Environmental Epidemiology
Environmental Epidemiology Medicine-Public Health, Environmental and Occupational Health
CiteScore
5.70
自引率
2.80%
发文量
71
审稿时长
25 weeks
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