枪叶桉提取物对α-突触核蛋白淀粉样纤维的抑制作用

IF 1.4 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Masatomo So, Misaki Ono, Shigeki Oogai, Minako Kondo, Kaede Yamazaki, Charlotte Nachtegael, Hiroshi Hamajima, Risa Mutoh, Masaki Kato, Hisaya Kawate, Tomoyuki Oki, Yasushi Kawata, Shiho Kumamoto, Noritaka Tokui, Toshiki Takei, Kuniyoshi Shimizu, Akio Inoue, Naoki Yamamoto, Motoko Unoki, Kenichi Tanabe, Kinichi Nakashima, Hiroyuki Sasaki, Hironobu Hojo, Yasuo Nagata, Isao Suetake
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引用次数: 0

摘要

淀粉样纤维的形成与各种淀粉样变性疾病有关,包括阿尔茨海默氏症和帕金森氏症等神经退行性疾病。尽管对抑制淀粉样蛋白形成进行了大量研究,但大多数淀粉样蛋白相关疾病的预防和治疗仍面临挑战。在这项研究中,我们研究了多种植物提取物对α-突触核蛋白淀粉样蛋白形成的影响。我们发现,炮叶桉的提取物能够在体外抑制淀粉样蛋白的形成,并分解预先形成的纤维。萃取物本身不会导致细胞损伤。在萃取物中,miquelianin 是槲皮素的糖基化形式,已在血浆和大脑中检测到,经鉴定和评估,与鞣花酸和槲皮素相比,miquelianin 的抑制活性适中,而鞣花酸和槲皮素是淀粉样蛋白形成的强抑制剂。miquelianin的特性使人们对大脑中α-突触核蛋白的组装控制机制有了更深入的了解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils.

Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite the numerous studies on the inhibition of amyloid formation, the prevention and treatment of a majority of amyloid-related disorders are still challenging. In this study, we investigated the effects of various plant extracts on amyloid formation of α-synuclein. We found that the extracts from Eucalyptus gunnii are able to inhibit amyloid formation, and to disaggregate preformed fibrils, in vitro. The extract itself did not lead to cell damage. In the extract, miquelianin, which is a glycosylated form of quercetin and has been detected in the plasma and the brain, was identified and assessed to have a moderate inhibitory activity, compared to the effects of ellagic acid and quercetin, which are strong inhibitors for amyloid formation. The properties of miquelianin provide insights into the mechanisms controlling the assembly of α-synuclein in the brain.

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来源期刊
Bioscience, Biotechnology, and Biochemistry
Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
183
审稿时长
1 months
期刊介绍: Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).
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