NOS3-rs1799983和NOS3-rs2070744 SNP在COVID-19后并发症血管坏死中的作用。

IF 2.1 4区 医学 Q3 GENETICS & HEREDITY
Eman Abd Allah Mahmoud Fouda, Eman Ae Badr, Doaa Gawesh, Mohammad A Mahmoud
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引用次数: 0

摘要

血管性坏死(AVN)是一种使人衰弱的疾病,其特点是骨组织因供血不足而坏死,导致关节功能障碍和塌陷。本研究调查了 AVN 与 COVID-19 之间的潜在关联,重点关注 NOS3 多态性等遗传因素。研究共纳入 180 人,包括 120 名 COVID-19 患者和 60 名健康对照者。对临床、血液学、生化和遗传参数进行了评估。结果显示,AVN 组和对照组在呼吸和心率、血液计数和生化指标方面存在明显差异。遗传分析表明,在 AVN 患者中,NOS3 rs1799983 多态性的 TG 基因型和 G 等位基因的患病率较高。此外,NOS3 rs2070744 多态性还与血压、心率和血液指标等各种临床参数相关。本研究强调了遗传因素在感染 COVID-19 后易患 AVN 的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of NOS3-rs1799983 and NOS3- rs2070744 SNP in occurrence of avascular necrosis as a post COVID-19 complication.

Avascular necrosis (AVN) is a debilitating condition characterized by bone tissue death due to inadequate blood supply, leading to joint dysfunction and collapse. This study investigates the potential association between AVN and COVID-19, focusing on genetic factors such as NOS3 polymorphisms. A total of 180 individuals were included, comprising 120 COVID-19 patients and 60 healthy controls. Clinical, haematological, biochemical, and genetic parameters were assessed. Results revealed significant differences in respiratory and heart rates, haematological counts, and biochemical markers between AVN and control groups. Genetic analysis showed a higher prevalence of the TG genotype and G allele in NOS3 rs1799983 polymorphism among AVN patients. Additionally, NOS3 rs2070744 polymorphism correlated with various clinical parameters, including blood pressure, heart rate, and haematological indices. This study highlights the potential role of genetic factors in predisposing individuals to AVN following COVID-19 infection.

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来源期刊
BMC Medical Genomics
BMC Medical Genomics 医学-遗传学
CiteScore
3.90
自引率
0.00%
发文量
243
审稿时长
3.5 months
期刊介绍: BMC Medical Genomics is an open access journal publishing original peer-reviewed research articles in all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.
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