驾驭联系:急性中风的急性肾损伤--前瞻性队列研究。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2024-07-01 Epub Date: 2024-08-22 DOI:10.4103/aian.aian_177_24
Sameer Arora, Arpit Agrawal, Venugopalan Y Vishnu, Mamta B Singh, Vinay Goyal, Padma M V Srivastava
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引用次数: 0

摘要

背景:急性肾损伤(AKI)在急性卒中患者中很常见。虽然 AKI 与不良临床预后有关,但有关其发病率及其对中风预后影响的数据却很有限:这是一项前瞻性观察研究,在一家三级医疗中心进行,分析了 204 名急性缺血性卒中和脑出血患者的数据。以入院时的血清肌酐为基线,住院 7 天内血清肌酐值在 48 小时内上升 0.3 mg/dl,或比基线上升至少 50%,即定义为 AKI。主要结果是测量急性脑卒中患者中 AKI 的发生率。次要结果指标包括全因死亡率、住院时间、透析需求以及缺血性和出血性中风的结果比较。对于两种中风亚型,我们都采用了多变量逻辑回归模型,以 AKI 和住院死亡率为结果。协变量包括性别、年龄、呼吸机需求、住院时间和入院时美国国立卫生研究院卒中量表评分:结果:144 例缺血性中风患者中有 12 例死亡(8.3%),60 例颅内出血(ICH)患者中有 22 例死亡(36.7%)。平均年龄为 55 岁,72.6% 为男性,34% 的缺血性中风和 66.7% 的 ICH 住院病例合并有 AKI。在按卒中类型分层的多变量分析中,AKI 与缺血性卒中住院死亡率(几率比 [OR] 27.21,95% CI 3.39-218.13)和出血性卒中住院死亡率(OR 5.12,95% CI 1.29-20.28)的增加有关:结论:AKI 常常并发中风并增加住院死亡率。结论:AKI 常常并发中风并增加住院死亡率,需要更多的研究来评估两者之间是否存在因果关系,以及预防 AKI 的措施是否会降低死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Navigating the Nexus: Acute Kidney Injury in Acute Stroke - A Prospective Cohort Study.

Background: Acute kidney injury (AKI) is prevalent in patients with acute stroke. Although AKI is linked to poor clinical outcomes, data about its incidence and effect on stroke outcomes is limited.

Methods: This was a prospective observational study carried out at a single tertiary care center that analyzed the data of 204 consecutive subjects with acute ischemic stroke and intracerebral hemorrhage. Considering serum creatinine at admission as the baseline, AKI was defined as a rise in serum creatinine value of 0.3 mg/dl over 48 h or a percentage increase of at least 50% from baseline over 7 days during hospitalization. The primary outcome was to measure the prevalence of AKI in patients with acute stroke. Secondary outcome measures were all-cause mortality, duration of hospital stay, need for dialysis, and comparison of outcomes in ischemic and hemorrhagic stroke. For both the stroke subtypes, we employed a multivariate logistic regression model, with AKI and hospital mortality being the outcomes. Covariates included gender, age, ventilatory requirement, duration of hospital stay, and National Institutes of Health Stroke Scale score at admission.

Results: There were 144 cases of ischemic stroke with 12 deaths (8.3%) and 60 cases of intracranial hemorrhage (ICH) with 22 deaths (36.7%). The mean age was 55 years, 72.6% were males, and AKI complicated 34% of ischemic stroke and 66.7% of ICH hospitalizations. AKI was linked to increased hospital mortality from ischemic stroke (odds ratio [OR] 27.21, 95% CI 3.39-218.13) and hemorrhagic stroke (OR 5.12, 95% CI 1.29-20.28) in multivariate analysis stratified by stroke type.

Conclusions: AKI complicates stroke frequently and increases hospital mortality. Additional studies are required to assess if the association is causal and if remedies to prevent AKI would decrease mortality.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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