细胞氧化剂与蛋白稳态网络:激活与破坏之间的平衡。

IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
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引用次数: 0

摘要

蛋白质失衡(蛋白稳态)是衰老和与年龄相关疾病的常见特征。蛋白稳态网络(PN)被认为是蛋白稳态的守护者,其作用是在蛋白质的生命周期内保持蛋白质的功能。然而,它的活性会随着年龄的增长而下降,从而导致疾病的发生。虽然活性氧(ROS)传统上被认为是这一过程的罪魁祸首,但最近的研究对这一观点提出了挑战。虽然高浓度的活性氧对人体有害,但适度的活性氧可通过激活分子伴侣、应激反应途径和自噬作用,保护细胞免受衰老介导的蛋白毒性的影响。这篇综述探讨了 ROS 在蛋白稳态中的微妙作用,并讨论了有关 PN 氧化还原调节的最新发现及其在延长健康寿命和延缓与年龄相关的病症方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cellular oxidants and the proteostasis network: balance between activation and destruction

Loss of protein homeostasis (proteostasis) is a common hallmark of aging and age-associated diseases. Considered as the guardian of proteostasis, the proteostasis network (PN) acts to preserve the functionality of proteins during their lifetime. However, its activity declines with age, leading to disease manifestation. While reactive oxygen species (ROS) were traditionally considered culprits in this process, recent research challenges this view. While harmful at high concentrations, moderate ROS levels protect the cell against age-mediated onset of proteotoxicity by activating molecular chaperones, stress response pathways, and autophagy. This review explores the nuanced roles of ROS in proteostasis and discusses the most recent findings regarding the redox regulation of the PN and its potential in extending healthspan and delaying age-related pathologies.

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来源期刊
Trends in Biochemical Sciences
Trends in Biochemical Sciences 生物-生化与分子生物学
CiteScore
22.90
自引率
0.70%
发文量
148
审稿时长
6-12 weeks
期刊介绍: For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.
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