确定暴露于极端温度和先天性心脏病的关键窗口。

IF 3 3区 地球科学 Q2 BIOPHYSICS
Huanhuan Zhang, Yang Feng, Jia Huang, Fenghua Zhang, Sisi Zhuo, Hongyan Liu
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引用次数: 0

摘要

大气温度与先天性心脏病(CHD)及其亚型之间的关系尚无定论。在这项基于人群的回顾性病例对照研究中,我们通过分布式滞后非线性模型分析了643例先天性心脏病病例和3215例非先天性心脏病对照,以估计每周气温暴露对先天性心脏病风险的影响,并确定潜在的易感窗口。通过二元逻辑回归模型,我们发现妊娠前三个月体温升高与总的先天性心脏病和室间隔缺损(VSD)风险增加有关(OR:1.059,95% CI:1.002-1.119;OR:1.094,95% CI:1.005-1.190),而妊娠后三个月体温升高与房间隔缺损(ASD)风险显著正相关。然而,DLNM 的结果显示,每周平均气温与总心脏病风险和亚型心脏病风险之间存在非线性关系。暴露在极度、中度和轻度高温下会显著增加总的先天性心脏病、ASD 和 VSD 的风险,临界窗口主要集中在妊娠的第 5-11 周和第 23-27 周。低温极端暴露仅导致 ASD 的易感窗口:第 13-14 孕周。在极端温度与动脉导管未闭或法洛氏四联症之间没有发现明显的正相关。在当前气候变化的背景下,我们的研究结果为目前了解高温和低温极端暴露对先天性心脏病及其主要亚型的影响提供了新的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Identifying the critical windows of temperature extremes exposure and congenital heart diseases

Identifying the critical windows of temperature extremes exposure and congenital heart diseases

The associations between atmospheric temperature and congenital heart disease (CHD) and its subtypes are still inconclusive. In this population-based retrospective case-control study, 643 CHD cases and 3,215 non-CHD controls were analyzed through distributed lag nonlinear model to estimate the effect of weekly temperature exposure on CHD risk and to identify potentially vulnerable windows. Through the binary logistic regression model, we found that elevated temperature in the first trimester was associated with an increased risk of overall CHD and ventricular septal defect (VSD) (OR: 1.059, 95% CI: 1.002–1.119; OR: 1.094, 95% CI: 1.005–1.190, respectively), while increased temperature in the second trimester was significantly positively correlated with atrial septal defect (ASD) risk. However, the results of the DLNM showed a nonlinear relationship between the weekly average temperature and the risk of total CHDs and the subtypes. Exposure to extremely, moderately, and mildly high temperatures significantly increased the risk of overall CHD, ASD and VSD, and the critical windows were mainly concentrated at the 5th-11th and 23rd-27th weeks of gestation. Low-temperature extreme exposure resulted in vulnerable windows for ASD only: 13th-14th gestational weeks. No significant positive associations were found between extreme temperature and patent ductus arteriosus or tetralogy of Fallot. In the current context of climate change, our results add new evidence to the present understanding of the effects of high- and low-temperature extreme exposure on CHD and its main subtypes.

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来源期刊
CiteScore
6.40
自引率
9.40%
发文量
183
审稿时长
1 months
期刊介绍: The Journal publishes original research papers, review articles and short communications on studies examining the interactions between living organisms and factors of the natural and artificial atmospheric environment. Living organisms extend from single cell organisms, to plants and animals, including humans. The atmospheric environment includes climate and weather, electromagnetic radiation, and chemical and biological pollutants. The journal embraces basic and applied research and practical aspects such as living conditions, agriculture, forestry, and health. The journal is published for the International Society of Biometeorology, and most membership categories include a subscription to the Journal.
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