光漂白介导的电荷可转换环糊精纳米粒子实现肿瘤深层穿透,用于直肠癌治疗技术

IF 38.1 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Duy-Thuc Nguyen, Min-Jun Baek, Sang Min Lee, Dahan Kim, So-Yeol Yoo, Jae-Young Lee, Dae-Duk Kim
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引用次数: 0

摘要

尽管电荷转换纳米粒子(NPs)有可能深入穿透肿瘤,但传统的电荷转换策略存在局限性,包括选择性低以及在肿瘤微环境中转换速度慢且不一致。在这项研究中,我们合成了一种七甲氰基环糊精衍生物的齐聚物近红外环糊精衍生物,并将其与二茂铁结合的pheophorbide复合物制成了多功能治疗纳米疗法。我们的 NPs 具有更强的肿瘤靶向能力,可对直肠肿瘤进行高特异性成像,肿瘤与直肠的信号比高达 7.8。在 880 纳米近红外激光照射下,NPs 的齐聚物表面电荷在肿瘤内迅速转化为阳离子电荷,促进 NPs 通过转囊作用穿透肿瘤。穿透后,使用 660 纳米激光启动光动力/化学动力疗法。我们的 NPs 根除了临床上相关大小的异位肿瘤(约 250 立方毫米)和正位直肠肿瘤,显示了其作为靶向直肠癌的治疗纳米平台的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics

Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics

Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics
Although charge-converting nanoparticles (NPs) potentially penetrate tumours deeply, conventional charge conversion strategies possess limitations, including low selectivity and slow, inconsistent conversion rate within the tumour microenvironment. In this study, we synthesized a zwitterionic near-infrared cyclodextrin derivative of heptamethine cyanine and complexed it with pheophorbide-conjugated ferrocene to produce multifunctional theranostic nanotherapeutics. Our NPs demonstrated enhanced tumour-targeting ability, enabling the highly specific imaging of rectal tumours, with tumour-to-rectum signal ratios reaching up to 7.8. The zwitterionic surface charge of the NPs was rapidly converted to a cationic charge within the tumours on 880 nm near-infrared laser irradiation, promoting the tumoural penetration of NPs via transcytosis. After penetration, photodynamic/chemodynamic therapy was initiated using a 660 nm laser. Our NPs eradicated clinically relevant-sized heterotopic tumours (~250 mm3) and orthotopic rectal tumours, displaying their potential as theranostic nanoplatforms for targeting rectal cancer. The photobleaching property of heptamethine cyanine enables efficient charge conversion of nanoparticles. Here heptamethine-cyanine-based nanoparticles achieve specific tumour imaging, deep tumour penetration and high therapeutic efficacy in rectal cancer animal models.
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来源期刊
Nature nanotechnology
Nature nanotechnology 工程技术-材料科学:综合
CiteScore
59.70
自引率
0.80%
发文量
196
审稿时长
4-8 weeks
期刊介绍: Nature Nanotechnology is a prestigious journal that publishes high-quality papers in various areas of nanoscience and nanotechnology. The journal focuses on the design, characterization, and production of structures, devices, and systems that manipulate and control materials at atomic, molecular, and macromolecular scales. It encompasses both bottom-up and top-down approaches, as well as their combinations. Furthermore, Nature Nanotechnology fosters the exchange of ideas among researchers from diverse disciplines such as chemistry, physics, material science, biomedical research, engineering, and more. It promotes collaboration at the forefront of this multidisciplinary field. The journal covers a wide range of topics, from fundamental research in physics, chemistry, and biology, including computational work and simulations, to the development of innovative devices and technologies for various industrial sectors such as information technology, medicine, manufacturing, high-performance materials, energy, and environmental technologies. It includes coverage of organic, inorganic, and hybrid materials.
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