利用 ATP 生物传感器了解肾细胞的能量

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2024-08-20 DOI:10.1016/j.kint.2024.06.019

János Peti-Peterdi , Georgina Gyarmati

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引用次数: 0

摘要

Yamamoto 等人开发了一项令人兴奋的先进技术，在完整的活体肾脏组织（包括位于肾脏表面深处的肾小管和血管节段）中以单细胞分辨率检测细胞内三磷酸腺苷水平。这项工作是对之前体内生物传感器研究的重大突破，可以从机理上研究细胞新陈代谢的改变、肾脏疾病的病理生物学以及药物治疗对不同肾脏细胞类型能量来源的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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See the power in kidney cells with ATP biosensor

Yamamoto et al. developed an exciting technical advance to examine intracellular adenosine triphosphate levels with single-cell resolution in intact living kidney tissue, including in tubular and vascular segments that lie deep under the kidney surface. The work is a significant advance on prior in vivo biosensor studies, and it allows for mechanistic investigation of alterations in cell metabolism, kidney disease pathobiology, and the effects of drug treatments on energy sources in different kidney cell types.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.