血液系统恶性肿瘤住院患者静脉血栓形成的发生率和风险因素:单中心前瞻性队列研究。

Northern clinics of Istanbul Pub Date : 2024-08-02 eCollection Date: 2024-01-01 DOI:10.14744/nci.2023.92332
Nevin Alayvaz Aslan, Ozde Elver, Cansu Korkmaz, Hande Senol, Alperen Halil Hayla, Nil Guler
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引用次数: 0

摘要

目的:血液系统恶性肿瘤患者的静脉血栓栓塞症(VTE)发病率高于预期,住院时间长会增加血栓形成的风险。本研究旨在调查血液系统恶性肿瘤住院患者静脉血栓形成的发生率和风险因素:我们设计了一项前瞻性队列研究,招募了 2020 年至 2021 年期间住院的血液系统恶性肿瘤患者。除出血风险较高的患者外,所有患者均接受了血栓预防治疗:结果:94 名患者入选。浅静脉血栓形成的发生率为 11.7%,深静脉血栓形成(包括肺栓塞和导管血栓形成)的发生率为 7.4%。与未发生血栓的患者相比,发生血栓的患者住院时间(21 天对 11.5 天,P=0.023)和住院次数(1 次对 3 次,P=0.015)明显更长。有 3 个或更多血栓形成风险因素的患者风险最高。(P=0.017,OR=4.32;95% CI:1.3-14.35)。此外,反复住院(p=0.024,OR=1.49;95% CI:1.05-2.11)和纤维蛋白原水平较高(p=0.028,OR=1;95% CI:1-1.006)的患者患血栓的风险也较高:结论:静脉血栓是血液系统恶性肿瘤住院患者的常见病。结论:血液系统恶性肿瘤住院患者中经常出现静脉血栓,需要一个普遍接受的风险评分系统来检测血栓高危患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incidence of and risk factors for venous thrombosis in hospitalized patients with hematologic malignancies: A single-center, prospective cohort study.

Objective: Incidence of venous thromboembolism (VTE) is higher than the expected in patients with hematologic malignancies and duration of hospitalization period increases the risk of thrombosis. The objective of this study was to investigate the incidence of and risk factors for venous thrombosis in hospitalized patients with hematologic malignancies.

Methods: We designed a prospective cohort study and enrolled patients with hematologic malignancies, who had been hospitalized between 2020 and 2021. Thromboprophylaxis was given to all patients, other than those under a high risk of hemorrhage.

Results: 94 patients were enrolled. The incidence of superficial vein thrombosis was 11.7% and the incidence of deep vein thrombosis (including pulmonary embolism and catheter thrombosis) was 7.4%. Patients, who developed thrombosis, had statistically significantly longer hospital stays (21 vs. 11.5 days, p=0.023) and a higher number of hospitalizations (1 vs. 3, p=0.015) compared to those, who did not develop thrombosis. Patients, who had 3 or more risk factors for thrombosis, were found to be under the highest risk. (p=0.017, OR=4.32; 95% CI: 1.3-14.35). Furthermore, patients with recurrent hospitalizations (p=0.024, OR=1.49; 95% CI: 1.05-2.11) and higher fibrinogen levels (p=0.028, OR=1; 95% CI: 1-1.006) were under an increased risk of thrombosis.

Conclusion: Venous thrombosis is frequently seen in hospitalized patients with hematologic malignancies. A universally accepted risk scoring system is required for detection of patients, under a high risk for thrombosis.

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