姜黄素-哌啶补充剂对 2 型糖尿病和高甘油三酯血症患者血脂、血糖指数、炎症和血压的影响。

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Hanie Hosseini, Mohammad Bagherniya, Amirhossein Sahebkar, Bijan Iraj, Muhammed Majeed, Gholamreza Askari
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引用次数: 0

摘要

2 型糖尿病(T2DM)是一种代谢紊乱疾病,与胰岛素抵抗以及随之而来的血糖异常、血脂异常和炎症有关。鉴于姜黄素-哌啶组合可能具有代谢方面的益处,我们探讨了这一组合在改善 T2DM 和高甘油三酯血症患者心脏代谢指标方面的疗效。在这项双盲临床试验中,72 名患有 T2DM 和高甘油三酯血症的患者被随机分配到含有 500 毫克姜黄素和 5 毫克胡椒碱的片剂或匹配的安慰剂中,接受为期 12 周的治疗。在基线和研究结束时对人体测量指数、血压、血糖指数、血脂概况、C反应蛋白(CRP)、生活质量和情绪进行评估。干预 12 周后,与安慰剂组相比,姜黄素-哌啶组的甘油三酯水平(p 值 = 0.001)和空腹血糖水平(p 值 = 0.004)显著降低。与安慰剂组相比,姜黄素-胡椒碱组的 CRP 水平略有降低(p 值 = 0.081)。此外,与对照组相比,姜黄素-胡椒碱组的能量/疲劳明显增加(p 值 = 0.024)。然而,组间比较显示,研究组之间的其他参数,包括人体测量指数(腰围和体重指数(BMI))、生化参数(低密度脂蛋白(LDL-c)、高密度脂蛋白(HDL-c)和胰岛素)、HOMA-IR、血压、生活质量和 DASS-21 项目均无明显变化(P 值大于 0.05)。本研究表明,姜黄素-哌啶补充剂可改善 T2DM 和高甘油三酯血症患者的血清 CRP、甘油三酯和血糖浓度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in patients with type 2 diabetes mellitus and hypertriglyceridemia.

Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with insulin resistance and ensuing dysglycemia, dyslipidemia, and inflammation. Owing to the putative metabolic benefits of curcumin-piperine combination, we explored the efficacy of this combination in improving cardiometabolic indices of patients with T2DM and hypertriglyceridemia. In this double-blind clinical trial, 72 patients with T2DM and hypertriglyceridemia were randomized to receive either a tablet containing 500 mg of curcuminoids plus 5 mg of piperine, or a matched placebo for 12 weeks. Anthropometric indices, blood pressure, glycemic indices, lipid profile, C-reactive protein (CRP), quality of life, and mood were evaluated at baseline and end of the study. After 12 weeks of intervention, the levels of triglycerides (p-value = 0.001) and fasting blood glucose (p-value = 0.004) were significantly reduced in the curcumin-piperine compared with the placebo group. CRP levels were marginally reduced in the curcumin-piperine compared with the placebo group (p-value = 0.081). In addition, energy/fatigue significantly increased in the curcumin-piperine group compared to the control group (p-value = 0.024). However, between-group comparisons showed no significant change in other parameters, including anthropometric indices (waist circumference and body mass index (BMI)), biochemical parameters (low-density lipoprotein (LDL-c), high-density lipoprotein (HDL-c), and insulin), HOMA-IR, blood pressure, quality of life, and DASS-21 items between the studied groups (p-value >0.05). The current study showed that curcumin-piperine supplementation can improve serum CRP, triglycerides, and glucose concentrations in patients with T2DM and hypertriglyceridemia.

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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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