PDZK1 下调与 OA 线粒体功能障碍有关。

IF 29.4 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2024-08-20 DOI:10.1038/s41584-024-01157-x

Maria Papatriantafyllou

引用次数: 0

摘要

含 PDZ 结构域的支架蛋白 PDZK1 在骨关节炎软骨细胞中下调，并与线粒体功能障碍和软骨细胞衰老有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

PDZK1 downregulation linked to mitochondrial dysfunction in OA

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PDZK1 downregulation linked to mitochondrial dysfunction in OA

The PDZ domain-containing scaffold protein PDZK1 is downregulated in osteoarthritic chondrocytes and is linked to mitochondrial dysfunction and chondrocyte senescence.

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.