疼痛和抑郁症状并存是否会加速认知能力的衰退?

IF 2.8 3区 医学 Q3 GERIATRICS & GERONTOLOGY
Patrícia Silva Tofani, Roberta de Oliveira Máximo, Natália Cochar-Soares, Paula Camila Ramírez, Mariane Marques Luiz, Sara Souza Lima, Thaís Barros Pereira da Silva, Thales Batista de Souza, Letícia Coelho Silveira, Valdete Regina Guandalini, Andrew Steptoe, Cesar de Oliveira, Tiago da Silva Alexandre
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引用次数: 0

摘要

目标:调查疼痛和抑郁症状是否是 50 岁以上老年人认知能力下降的风险因素:调查疼痛和抑郁症状并存是否是 50 岁或以上人群认知能力下降的风险因素:方法:对英国老龄化纵向研究(ELSA)的4718名参与者进行纵向轨迹研究。关节疼痛由参与者自我报告,疼痛程度分为轻度、中度和重度。抑郁症状采用流行病学研究中心抑郁量表(CES-D-8 ≥ 4)进行调查。样本分为六组:无痛无抑郁(NP/NDE)、轻度疼痛无抑郁(MP/NDE)、中度/重度疼痛无抑郁(M-IP/NDE)、无痛有抑郁(NP/De)、轻度疼痛有抑郁(MP/De)、中度/重度疼痛有抑郁(M-IP/De)。研究结果关注的是记忆、执行功能和整体认知方面的表现。研究人员使用广义线性混合模型分析了随访12年期间认知领域的表现和总体认知得分与疼痛和抑郁症状的关系:结果:随着时间的推移,M-IP/De 患者的记忆力下降(-0.038 SD/年,95%CI:-0.068 至 -0.007)和总体认知得分(-0.033 SD/年,95%CI:-0.063 至 -0.002)均高于 NP/NDe 患者:结论:中度/剧烈疼痛与抑郁症状并存是导致整体认知能力和记忆力下降的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does the coexistence of pain and depressive symptoms accelerate cognitive decline?

Objectives: Investigate whether the coexistence of pain and depressive symptoms is a risk factor for cognitive decline in individuals aged 50 or older.

Method: Longitudinal trajectory study involving 4,718 participants from the English Longitudinal Study of Ageing (ELSA). Joint pain was self-reported, and intensity was classified as mild, moderate/intense. Depressive symptoms were investigated using the Centre for Epidemiologic Studies Depression Scale (CES-D-8 ≥ 4). The sample was divided into six groups: no pain and no depression (NP/NDe), mild pain and no depression (MP/NDe), moderate/intense pain and no depression (M-IP/NDe), no pain and depression (NP/De), mild pain and depression (MP/De), and moderate/intense pain and depression (M-IP/De). The outcome of interest was performance in memory, executive function, and global cognition. Generalised linear mixed models were used to analyse performance in the cognitive domains and global cognition score as a function of pain and depressive symptoms during 12 years of follow-up.

Results: Over time, individuals with M-IP/De had a greater memory decline (-0.038 SD/year, 95%CI: -0.068 to -0.007) and the global cognition score (-0.033 SD/year, 95%CI: -0.063 to -0.002) than those with NP/NDe.

Conclusion: The coexistence of moderate/intense pain and depressive symptoms is a risk factor for the decline of global cognition and memory.

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来源期刊
Aging & Mental Health
Aging & Mental Health 医学-精神病学
CiteScore
7.00
自引率
2.90%
发文量
176
审稿时长
4-8 weeks
期刊介绍: Aging & Mental Health provides a leading international forum for the rapidly expanding field which investigates the relationship between the aging process and mental health. The journal addresses the mental changes associated with normal and abnormal or pathological aging, as well as the psychological and psychiatric problems of the aging population. The journal also has a strong commitment to interdisciplinary and innovative approaches that explore new topics and methods. Aging & Mental Health covers the biological, psychological and social aspects of aging as they relate to mental health. In particular it encourages an integrated approach for examining various biopsychosocial processes and etiological factors associated with psychological changes in the elderly. It also emphasizes the various strategies, therapies and services which may be directed at improving the mental health of the elderly and their families. In this way the journal promotes a strong alliance among the theoretical, experimental and applied sciences across a range of issues affecting mental health and aging. The emphasis of the journal is on rigorous quantitative, and qualitative, research and, high quality innovative studies on emerging topics.
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