G Daidone, D Raffa, M L Bajardi, S Plescia, M Milici
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引用次数: 0
摘要
制备了新型N-(3-甲基-4- r -异恶唑-5-基)-2- r1 -4- r2 -苯氧乙酰胺和N-(3-甲基-4- r -异恶唑-5-基)-2-(2- r1 -4- r2 -苯氧乙酰胺)苯酰胺，并对白色念珠菌和新生隐球菌进行了抑菌试验。抗菌试验结果表明，两个酰胺基团的存在通常增强了抗真菌活性。
[Derivatives of phenoxyacetamide and antimycotic activity].
Novel N-(3-methyl-4-R-isoxazol-5-yl)-2-R1-4-R2-phenoxyacetamides and N-(3-methyl-4-R-isoxazol-5-yl)-2-(2-R1-4-R2-phenoxyacetamido) benzamides were prepared and tested against Candida albicans and Cryptococcus neoformans. The results of the antimicrobial assay showed that the presence of two amidic groups usually enhances antimycotic activity.
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