针对母体代谢环境进行精准干预,促进肥胖孕妇健康怀孕。

IF 5.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Current Diabetes Reports Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI:10.1007/s11892-024-01550-6
Alexandra M Niclou, Hannah E Cabre, Emily W Flanagan, Leanne M Redman
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引用次数: 0

摘要

审查目的:妊娠期肥胖会增加父母和胎儿出现不良健康后果的风险。因此,研究干预措施主要集中在限制孕期体重增加过多,尤其是肥胖孕妇。然而,尽管许多生活方式干预措施都能成功降低妊娠期体重增加,但影响妊娠结局的干预措施却寥寥无几。在此,我们回顾了针对新陈代谢环境而非仅仅关注体重的工作:在非妊娠人群中开展的工作表明,专门针对葡萄糖、甘油三酯和瘦素水平或炎症制造商的干预措施可改善代谢环境和整体健康。我们认为,包括限制进食时间、遵守 24 小时运动指南或减少孕期久坐行为等策略在内的精准干预措施可以成功改善孕产妇的新陈代谢环境,并将不良妊娠结局的风险降至最低。连续血糖监测仪等个性化工具或基于社区的方法在孕前保健中发挥着重要作用,应推广到孕期干预中,使代谢环境直接受益,优化父母和孩子的健康结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Precision Interventions Targeting the Maternal Metabolic Milieu for Healthy Pregnancies in Obesity.

Precision Interventions Targeting the Maternal Metabolic Milieu for Healthy Pregnancies in Obesity.

Purpose of review: Entering pregnancy with obesity increases the risk of adverse health outcomes for parent and child. As such, research interventions are largely focused on limiting excess gestational weight gain during pregnancy, especially in those with obesity. Yet, while many lifestyle interventions are successful in reducing GWG, few affect pregnancy outcomes. Here we review work targeting the metabolic milieu instead of focusing solely on weight.

Recent findings: Work done in non-pregnant populations suggests that specifically targeting glucose, triglyceride, and leptin levels or inflammatory makers improves the metabolic milieu and overall health. We posit that precision interventions that include strategies such as time restricted eating, following the 24 h movement guidelines, or reducing sedentary behavior during pregnancy can be successful approaches benefiting the maternal metabolic milieu and minimize the risk of adverse pregnancy outcomes. Personalized tools such as continuous glucose monitors or community-based approaches play an important role in pre-conception health and should be extrapolated to pregnancy interventions to directly benefit the metabolic milieu optimizing health outcomes for both parent and child.

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来源期刊
CiteScore
9.80
自引率
0.00%
发文量
52
审稿时长
6-12 weeks
期刊介绍: The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of diabetes epidemiology, pathophysiology, and management. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
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