纳米颗粒进入细胞和组织：现状与挑战。

IF 2.6 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Beilstein Journal of Nanotechnology Pub Date : 2024-08-12 eCollection Date: 2024-01-01 DOI:10.3762/bjnano.15.83

Kirsten Sandvig, Tore Geir Iversen, Tore Skotland

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引用次数: 0

摘要

本文将讨论不同成分的纳米粒子（NPs）如何与细胞相互作用并被细胞内化，以及由此对细胞功能产生的影响。制造大量 NPs 的目的是为了改善癌症治疗，其目标是增加注射到肿瘤的药物比例，从而提高治疗效果并减少副作用。因此，我们将讨论如何将 NPs 运送到肿瘤，以及与生物分布、药代动力学和排泄研究相关的一些挑战。最后，我们讨论了将 NPs 应用于临床的要求，以及使用复杂、降解缓慢或不可降解的 NPs 所涉及的各个方面。

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Entry of nanoparticles into cells and tissues: status and challenges.

In this article we discuss how nanoparticles (NPs) of different compositions may interact with and be internalized by cells, and the consequences of that for cellular functions. A large number of NPs are made with the intention to improve cancer treatment, the goal being to increase the fraction of injected drug delivered to the tumor and thereby improve the therapeutic effect and decrease side effects. Thus, we discuss how NPs are delivered to tumors and some challenges related to investigations of biodistribution, pharmacokinetics, and excretion. Finally, we discuss requirements for bringing NPs into clinical use and aspects when it comes to usage of complex and slowly degraded or nondegradable NPs.

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来源期刊

Beilstein Journal of Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

5.70

自引率

3.20%

发文量

109

审稿时长

2 months

期刊介绍： The Beilstein Journal of Nanotechnology is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in nanoscience and nanotechnology. The journal is published and completely funded by the Beilstein-Institut, a non-profit foundation located in Frankfurt am Main, Germany. The editor-in-chief is Professor Thomas Schimmel – Karlsruhe Institute of Technology. He is supported by more than 20 associate editors who are responsible for a particular subject area within the scope of the journal.