通过电合成氧化转化利用肼的多功能性。

IF 2.2 4区 化学 Q2 CHEMISTRY, ORGANIC
Beilstein Journal of Organic Chemistry Pub Date : 2024-08-14 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.175
Aurélie Claraz
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引用次数: 0

摘要

肼是有机合成中重要的结构基团,为构建有价值的化合物提供了有用的分子平台。酰肼的电氧化转化为利用这些试剂的多功能性提供了一个极具吸引力的机会。通过直接利用电流来执行氧化过程,可以在温和、安全和无氧化剂的反应条件下,从现成的酰肼中获得大量有机分子。本综述全面概述了酰肼的氧化电合成转化。其中包括偶氮环的构建、醛基肼的 C(sp2)-H 功能化以及重氮化合物的合成中间体或产物的获得。该研究特别关注反应机理,以鼓励在这一领域的进一步发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Harnessing the versatility of hydrazones through electrosynthetic oxidative transformations.

Hydrazones are important structural motifs in organic synthesis, providing a useful molecular platform for the construction of valuable compounds. Electrooxidative transformations of hydrazones constitute an attractive opportunity to take advantage of the versatility of these reagents. By directly harnessing the electrical current to perform the oxidative process, a large panel of organic molecules can be accessed from readily available hydrazones under mild, safe and oxidant-free reaction conditions. This review presents a comprehensive overview of oxidative electrosynthetic transformations of hydrazones. It includes the construction of azacycles, the C(sp2)-H functionalization of aldehyde-derived hydrazones and the access to diazo compounds as either synthetic intermediates or products. A special attention is paid to the reaction mechanism with the aim to encourage further development in this field.

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来源期刊
CiteScore
4.90
自引率
3.70%
发文量
167
审稿时长
1.4 months
期刊介绍: The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.
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