肺移植术后一年的死亡率:2012年至2021年法国一家中心的经验。

IF 1.1 4区 医学 Q3 SURGERY
Thi Cam Tu Hoang, Lien Han, Sandrine Hirschi, Tristan Degot, Justine Leroux, Pierre-Emmanuel Falcoz, Anne Olland, Nicola Santelmo, Marion Villard, Olivier Collange, Gauthier Appere, Romain Kessler, Benjamin Renaud-Picard
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引用次数: 0

摘要

背景 肺移植(LTx)是一种针对特定肺部疾病晚期患者的延长生命疗法。本研究旨在评估 2012 年至 2021 年期间法国斯特拉斯堡大学医院肺移植术后 1 年死亡率的关联和原因。材料和方法 我们对 2012 年 1 月 1 日至 2021 年 12 月 31 日期间在斯特拉斯堡大学医院接受肺移植手术的 425 名患者进行了回顾性分析。我们从电子病历中收集了移植前、围手术期和术后数据。结果 在所有患者中,94.6%的患者进行了肺移植,4.0%的患者进行了心肺移植,1.4%的患者进行了胰岛肺移植。移植时的中位年龄为 57 岁,男性患者占 55.3%。51.1%的患者导致LTx的主要原发性肺部疾病是慢性阻塞性肺病;16.2%的患者需要进行超紧急LTx。1年死亡率为11.5%。大多数死亡原因是多器官功能衰竭或脓毒性休克。在多变量分析中,我们发现了与 LTx 术后 1 年死亡率显著相关的 3 个风险因素:体重指数(BMI)介于 25 至 30 kg/m² 与体重指数介于 18.5 至 25 kg/m² 之间(P=0.032)、术后体外膜氧合支持(P=0.034)和移植术后重症监护室住院时间(P=0.034)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
One-Year Mortality After Lung Transplantation: Experience of a Single French Center Between 2012 and 2021.

BACKGROUND Lung transplantation (LTx) is a life-extending therapy for specific patients with terminal lung diseases. This study aimed to evaluate the associations and causes of 1-year mortality after lung transplantation at Strasbourg University Hospital, France, between 2012 and 2021. MATERIAL AND METHODS We carried out a retrospective analysis on 425 patients who underwent LTx at Strasbourg University Hospital between January 1, 2012, and December 31, 2021. Pre-transplant, perioperative, and postoperative data were collected from the electronic medical records. RESULTS Among all patients, 94.6% had a LTx, 4.0% a heart-lung transplantation, and 1.4% underwent pancreatic islet-lung transplantation. The median age at transplantation was 57 years, with 55.3% male patients. The main native lung disease leading to LTx was chronic obstructive pulmonary disease in 51.1% of patients; 16.2% needed super-urgent LTx. The 1-year mortality rate was 11.5%. Most deaths were either caused by multi-organ failure or septic shock. In our multivariate analysis, we identified 3 risk factors significantly related to 1-year mortality after LTx: body mass index (BMI) between 25 and 30 kg/m² vs BMI between 18.5 and 25 kg/m² (P=0.032), postoperative extracorporeal membrane oxygenation support (P=0.034), and intensive care unit length of stay after transplantation (P<0.001). Two other factors were associated with a significantly lower 1-year mortality risk: longer hospital stay after LTx (P=0.024) and tacrolimus prescription (P=0.004). CONCLUSIONS Our study reported a 1-year mortality rate of 11.5% after LTx. Although LTx candidates are carefully selected, additional data are required to improve understanding of the risk factors for post-LTx mortality.

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来源期刊
CiteScore
2.50
自引率
0.00%
发文量
79
审稿时长
>12 weeks
期刊介绍: Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation. Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time to first decision is around 3-4 weeks. Time to publication of accepted manuscripts continues to be shortened, with the Editorial team committed to a goal of 3 months from acceptance to publication. Expert reseachers and clinicians from around the world contribute original Articles, Review Papers, Case Reports and Special Reports in every pertinent specialty, providing a lot of arguments for discussion of exciting developments and controversies in the field.
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