{"title":"甲壳动物 Hippo-Yki 途径的最新研究进展:甲壳动物水产养殖中的现有知识和潜在应用","authors":"Linwei Yang, Yushi Gan, Hengwei Deng, Jianguo He, Xiaopeng Xu","doi":"10.1111/raq.12955","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>The Hippo-YAP/Yki pathway is critical for the regulation of physiological responses in various biological processes from invertebrates to mammals. Crustaceans, in particular shrimp and crabs, are important food sources worldwide. In response to the needs of crustacean aquaculture and disease control, the regulatory mechanisms of crustacean life activities, especially immunity, have been increasingly emphasized. Emerging clues suggest that Hippo-Yki pathway is important for immunity and regeneration in crustaceans. In this review, the structure, activation pattern, response mechanism to pathogen invasion, and crosstalk with other signaling cascades of the Hippo-Yki pathway in aquaculture crustaceans are summarized and its similarities and differences with those in mammals and <i>Drosophila</i> are investigated. Based on this, the roles of the Hippo-Yki pathway in crustacean immune response and limb regeneration are further discussed, and the application potential of strategies pharmacologically or biologically targeting this pathway for crustacean disease control and breeding is theoretically explored.</p>\n </div>","PeriodicalId":227,"journal":{"name":"Reviews in Aquaculture","volume":"17 1","pages":""},"PeriodicalIF":8.8000,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent Research Advances on the Hippo-Yki Pathway of Crustaceans: Current Knowledge and Potential Applications in Crustacean Aquaculture\",\"authors\":\"Linwei Yang, Yushi Gan, Hengwei Deng, Jianguo He, Xiaopeng Xu\",\"doi\":\"10.1111/raq.12955\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>The Hippo-YAP/Yki pathway is critical for the regulation of physiological responses in various biological processes from invertebrates to mammals. Crustaceans, in particular shrimp and crabs, are important food sources worldwide. In response to the needs of crustacean aquaculture and disease control, the regulatory mechanisms of crustacean life activities, especially immunity, have been increasingly emphasized. Emerging clues suggest that Hippo-Yki pathway is important for immunity and regeneration in crustaceans. In this review, the structure, activation pattern, response mechanism to pathogen invasion, and crosstalk with other signaling cascades of the Hippo-Yki pathway in aquaculture crustaceans are summarized and its similarities and differences with those in mammals and <i>Drosophila</i> are investigated. Based on this, the roles of the Hippo-Yki pathway in crustacean immune response and limb regeneration are further discussed, and the application potential of strategies pharmacologically or biologically targeting this pathway for crustacean disease control and breeding is theoretically explored.</p>\\n </div>\",\"PeriodicalId\":227,\"journal\":{\"name\":\"Reviews in Aquaculture\",\"volume\":\"17 1\",\"pages\":\"\"},\"PeriodicalIF\":8.8000,\"publicationDate\":\"2024-08-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reviews in Aquaculture\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/raq.12955\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"FISHERIES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reviews in Aquaculture","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/raq.12955","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FISHERIES","Score":null,"Total":0}
Recent Research Advances on the Hippo-Yki Pathway of Crustaceans: Current Knowledge and Potential Applications in Crustacean Aquaculture
The Hippo-YAP/Yki pathway is critical for the regulation of physiological responses in various biological processes from invertebrates to mammals. Crustaceans, in particular shrimp and crabs, are important food sources worldwide. In response to the needs of crustacean aquaculture and disease control, the regulatory mechanisms of crustacean life activities, especially immunity, have been increasingly emphasized. Emerging clues suggest that Hippo-Yki pathway is important for immunity and regeneration in crustaceans. In this review, the structure, activation pattern, response mechanism to pathogen invasion, and crosstalk with other signaling cascades of the Hippo-Yki pathway in aquaculture crustaceans are summarized and its similarities and differences with those in mammals and Drosophila are investigated. Based on this, the roles of the Hippo-Yki pathway in crustacean immune response and limb regeneration are further discussed, and the application potential of strategies pharmacologically or biologically targeting this pathway for crustacean disease control and breeding is theoretically explored.
期刊介绍:
Reviews in Aquaculture is a journal that aims to provide a platform for reviews on various aspects of aquaculture science, techniques, policies, and planning. The journal publishes fully peer-reviewed review articles on topics including global, regional, and national production and market trends in aquaculture, advancements in aquaculture practices and technology, interactions between aquaculture and the environment, indigenous and alien species in aquaculture, genetics and its relation to aquaculture, as well as aquaculture product quality and traceability. The journal is indexed and abstracted in several databases including AgBiotech News & Information (CABI), AgBiotechNet, Agricultural Engineering Abstracts, Environment Index (EBSCO Publishing), SCOPUS (Elsevier), and Web of Science (Clarivate Analytics) among others.