Heather E Mast, Pierre U Blier, Mirko Ɖorđević, Uroš Savković, Claudia D Holody, Stephane L Bourque, Hélène Lemieux
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引用次数: 0
摘要
线粒体在衰老过程中起着关键作用。在这里,我们测量了经过近 40 年早期繁殖(E)或晚期繁殖(L)选择的种子甲虫 Acanthoscelides obtectus 实验进化品系的线粒体综合功能。这两个品系的寿命明显不同(E 和 L 品系分别为 8 天和 13 天)。与 E 型甲虫相比,L 型甲虫在幼虫期的 NADH 途径对最大通量的贡献较低,这与复合体 I 的控制增加有关。我们的数据表明,繁殖年龄的选择导致线粒体中复合体 I 活性的调节,线粒体是衰老的进化理论和机理理论之间的功能性联系。
Selection for late reproduction leads to loss of complex I mitochondrial capacity and associated increased longevity in seed beetles.
Mitochondria play a key role in aging. Here, we measured integrated mitochondrial functions in experimentally evolved lines of the seed beetle Acanthoscelides obtectus that were selected for early (E) or late (L) reproduction for nearly four decades. The two lines have markedly different lifespans (8 days and 13 days in the E and L lines, respectively). The contribution of the NADH pathway to maximal flux was lower in the L compared to the E beetles at young stages, associated to increased control by complex I. In contrast, the contribution of the Succinate pathway was higher in the L than in the E line, while the Proline pathway showed no differences between the lines. Our data suggest that selection of age at reproduction leads to a modulation of complex I activity in mitochondria and that mitochondria are a functional link between evolutionary and mechanistic theories of aging.