肝细胞癌中细胞生存压力与 N6-甲基腺苷修饰之间的相互影响

IF 3.6 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Chu-Li Fu, Zheng-Wei Zhao, Qiang-Nu Zhang
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引用次数: 0

摘要

背景:在肿瘤微环境中,生存压力普遍存在,是肿瘤进展、血管生成和治疗耐药性的强大驱动力。N6-甲基腺苷(m6A)甲基化被认为是调控 mRNA 代谢各个方面的关键转录后机制。了解生存压力和 m6A 修饰之间错综复杂的相互作用为肝细胞癌(HCC)进展的分子机制提供了新的视角,并凸显了在 HCC 诊断和治疗中靶向生存压力-m6A 轴的潜力:在PubMed、MEDLINE和Web of Science上对截至2024年4月发表的相关文章进行了文献检索。搜索关键词包括肝细胞癌、细胞存活、存活压力、N6-甲基腺苷、肿瘤微环境、应激反应和缺氧:这篇综述深入探讨了生存压力和m6A RNA甲基化在HCC中的多方面作用,强调了生存压力如何调节m6A景观,m6A修饰对生存压力响应基因表达的影响,以及由此对HCC细胞生存、增殖、转移和耐药性的影响。此外,我们还探讨了针对这种串扰的治疗潜力,提出了利用对生存压力和 m6A RNA 甲基化机制的了解来开发新的、更有效的 HCC 治疗方法的策略:生存压力和 m6A RNA 甲基化之间的相互作用是影响 HCC 发病和进展的复杂调控网络。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The crosstalk between cellular survival pressures and N6-methyladenosine modification in hepatocellular carcinoma.

Background: Within the tumor microenvironment, survival pressures are prevalent with potent drivers of tumor progression, angiogenesis, and therapeutic resistance. N6-methyladenosine (m6A) methylation has been recognized as a critical post-transcriptional mechanism regulating various aspects of mRNA metabolism. Understanding the intricate interplay between survival pressures and m6A modification provides new insights into the molecular mechanisms underlying hepatocellular carcinoma (HCC) progression and highlights the potential for targeting the survival pressures-m6A axis in HCC diagnosis and treatment.

Data sources: A literature search was conducted in PubMed, MEDLINE, and Web of Science for relevant articles published up to April 2024. The keywords used for the search included hepatocellular carcinoma, cellular survival, survival pressure, N6-methyladenosine, tumor microenvironment, stress response, and hypoxia.

Results: This review delves into the multifaceted roles of survival pressures and m6A RNA methylation in HCC, highlighting how survival pressures modulate the m6A landscape, the impact of m6A modification on survival pressure-responsive gene expression, and the consequent effects on HCC cell survival, proliferation, metastasis, and resistance to treatment. Furthermore, we explored the therapeutic potential of targeting this crosstalk, proposing strategies that leverage the understanding of survival pressures and m6A RNA methylation mechanisms to develop novel, and more effective treatments for HCC.

Conclusions: The interplay between survival pressures and m6A RNA methylation emerges as a complex regulatory network that influences HCC pathogenesis and progression.

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来源期刊
CiteScore
5.40
自引率
6.10%
发文量
152
审稿时长
3.0 months
期刊介绍: Hepatobiliary & Pancreatic Diseases International (HBPD INT) (ISSN 1499-3872 / CN 33-1391/R) a bimonthly journal published by First Affiliated Hospital, Zhejiang University School of Medicine, China. It publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic diseases. Papers cover the medical, surgical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas under the headings Liver, Biliary, Pancreas, Transplantation, Research, Special Reports, Editorials, Review Articles, Brief Communications, Clinical Summary, Clinical Images and Case Reports. It also deals with the basic sciences and experimental work. The journal is abstracted and indexed in SCI-E, IM/MEDLINE, EMBASE/EM, CA, Scopus, ScienceDirect, etc.
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