精神病临床高危人群听觉稳态反应的 40 赫兹和完整分层组织模式受损。

IF 5.3 2区 医学 Q1 CLINICAL NEUROLOGY
Junjie Wang , Jin Li , Yingying Tang , Xu Liu , Zhenying Qian , Tianhong Zhang , Lihua Xu , Huiru Cui , Yanyan Wei , Li Hui , Jijun Wang
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引用次数: 0

摘要

背景:精神分裂症患者的伽玛波段振荡受损,尤其是40赫兹听觉稳态反应(ASSR),已被证实,但有关全面爆发精神病前ASSR特征的证据相对较少:目的:描述精神病临床高危人群(CHR)中伽马波段 ASSR 的特征:方法:纳入 107 名临床高危精神病(CHR)受试者和 65 名健康对照(HC)受试者,并完成临床评估、脑电图(EEG)ASSR 范式和认知评估。分别对两组受试者对20赫兹、30赫兹和40赫兹咔嗒声的事件相关频谱扰动(ERSP)和房室相干性(ITC)指标进行了测定和比较,并评估了它们与临床精神病理学和认知功能的关系:结果:在40Hz的咔嗒声中,HC组的ERSP(1.042 ± 0.047)比CHR组(0.873 ± 0.036)明显增加(P = 0.005);在30Hz的咔嗒声中,HC组的ERSP(0.536 ± 0.024)比CHR组(0.483±0.019),但差异有统计学意义(p = 0.083);在 20 赫兹,HC 组 ERSP(0.452±0.017)与 CHR 组 ERSP(0.418±0.013)无显著差异(p = 0.104)。HC组的ERSP在40Hz的咔嗒声中最高,其次是30Hz,最低的是20Hz。三种ERSP中任何两种之间的差异均有统计学意义(30Hz vs. 40Hz:p 结论:HC组的ERSP在40Hz咔嗒声中受损,但在20Hz咔嗒声中未受损:CHR人群的40赫兹听觉稳态分层组织模式受损,但未受损。慢性阻塞性肺病患者 40 赫兹听觉稳态异常可能与认知功能有关,如信息处理速度和视觉记忆。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impaired 40-Hz and intact hierarchical organization mode of auditory steady-state responses among individuals with clinical high-risk for psychosis

Background

Impaired gamma band oscillation, specifically 40-Hz auditory steady state response (ASSR) has been robustly found in schizophrenia, while there is relatively little evidence characterizing the ASSR before full-blown psychosis.

Objective

To characterize gamma-band ASSR in populations at clinical high-risk for psychosis (CHR).

Methods

One hundred and seven CHR subjects and sixty-five healthy control (HC) subjects were included and completed clinical assessments, the ASSR paradigm of electroencephalography (EEG) and cognitive assessments. Both indices of event-related spectrum perturbation (ERSP) and intertrial coherence (ITC) in response to 20-Hz, 30-Hz and 40-Hz click sounds were respectively qualified and compared between these two groups, as well as the relationship to clinical psychopathology and cognitive function was assessed.

Results

At 40-Hz click sounds, ERSP in HC group (1.042 ± 0.047) was statistical significantly increased than that in CHR group (0.873 ± 0.036) (p = 0.005);at 30-Hz, ERSP in HC group (0.536 ± 0.024) was increased than that in CHR group (0.483 ± 0.019), but the difference was trend statistical significance (p = 0.083);at 20-Hz, ERSP in HC group (0.452 ± 0.017) was not different significantly from CHR group (0.418 ± 0.013) (p = 0.104).

ERSP of the HC group was the highest at 40-Hz click sounds, followed by 30-Hz, and the lowest at 20-Hz. The difference between any two of the three ERSP showed statistical significance (30-Hz vs. 40-Hz: p < 0.001; 20-Hz vs. 40-Hz: p < 0.001;20-Hz vs. 30-Hz: p = 0.003). Similarly, ERSP of the CHR group was the highest at 40-Hz click sounds, followed by 30-Hz, and the lowest at 20-Hz. The difference between any two of these three ERSP showed statistical significance (30-Hz vs. 40-Hz: p < 0.001; 20-Hz vs. 40-Hz: p < 0.001;20-Hz vs. 30-Hz: p = 0.002).

A statistically significant small positive correlation of 40-Hz ERSP with signal processing speed score was observed in the HC group (ρ = 0.27, p = 0.029). A statistically significant small negative correlation of 40-Hz ERSP with visual learning score was observed in the CHR group (ρ = −0.22, p = 0.023).

Conclusion

Impaired 40-Hz but undamaged hierarchical organization mode of auditory steady state presented in the CHR populations. Abnormal 40 Hz ASSR for CHR might be associated with cognitive functions, such as information processing speed and visual memory.

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来源期刊
CiteScore
12.00
自引率
1.80%
发文量
153
审稿时长
56 days
期刊介绍: Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.
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