青蒿素通过上调 L1 细胞粘附分子改善成年雄性甲状腺功能减退大鼠的甲状腺功能和并发症。

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Lingling Li, Haifan Xu, Zecheng Hu, Li Li
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引用次数: 0

摘要

背景:甲状腺功能减退症是由甲状腺激素分泌不足引起的一种常见的世界性综合征,影响着不同年龄段的人群。青蒿素(ART)是众所周知的治疗疟疾的有效药物,在多种疾病中也具有抗氧化应激功能。L1 细胞粘附分子在疾病系统中发挥着多重保护作用。本研究旨在评估 ART 对成年雄性甲状腺功能减退大鼠的作用及其内在机制:丙基硫脲嘧啶(PTU)大鼠模型接受或不接受 5 mg/kg ART 和 L1 短干扰 RNA(siRNA)治疗,然后通过实验确定 ART 对甲状腺功能、抑郁和焦虑、认知障碍、肝脏、肾脏和心脏功能以及氧化应激的影响:本研究表明,ART能改善甲状腺功能,缓解抑郁和焦虑症状,减轻认知障碍,改善肝、肾和心脏功能,抑制氧化应激:这些结果表明,ART能上调L1细胞粘附分子,从而改善成年雄性甲减大鼠的甲状腺功能和并发症,为ART成为治疗甲减的一种新策略奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Artemisinin ameliorates thyroid function and complications in adult male hypothyroid rats via upregulation of the L1 cell adhesion molecule.

Background: Hypothyroidism, a common worldwide syndrome caused by insufficient thyroid hormone secretion, affects number of people at different ages. Artemisinin (ART), a well-known effective agent in the treatment of malaria, also has anti-oxidative stress functions in various diseases. The L1 cell adhesion molecule exerts multiple protective roles in diseased systems. The aim of the present study was to evaluate the role of ART in adult male hypothyroid rats and the underlying mechanisms.

Methods: The propylthiouracil (PTU) rat model was treated with or without 5 mg/kg ART and with or without L1 short-interfering RNA (siRNA), followed by the experiments to determine the effect of ART on thyroid function, depression and anxiety, cognition impairments, liver, kidney and heart functions, and oxidative stress.

Results: In the current study, it was shown that ART can ameliorate thyroid function, mitigate depression and anxiety symptoms, attenuate cognition impairments, improve liver, kidney and heart functions, and inhibit oxidative stress; however, the effects exerted by ART could not be observed when L1 was silenced by L1 siRNA.

Conclusion: These results indicated that ART can upregulate the L1 cell adhesion molecule to ameliorate thyroid function and the complications in adult male hypothyroid rats, laying the foundation for ART to be a novel strategy for the treatment of hypothyroidism.

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来源期刊
Thyroid Research
Thyroid Research Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
3.10
自引率
4.50%
发文量
21
审稿时长
8 weeks
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