经眶B型超声波评估特发性颅内高压患者球后扁平:一项试验研究。

IF 3.4 Q2 Medicine
Theresia Knoche, Charlotte Pietrock, Konrad Neumann, Mirjam Rossel-Zemkouo, Leon Alexander Danyel
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引用次数: 0

摘要

背景:球后扁平(PGF)是特发性颅内高压(IIH)患者的一种特殊神经影像学征象,但其检测是基于神经放射学的主观定性评估。本研究旨在评估经眶超声利用球后角(PGA)检测和量化特发性颅内高压(IIH)患者 PGF 的实用性:方法: 一项前瞻性病例对照研究连续招募了 IIH 患者和健康对照者。进行经眶超声检查以评估是否存在 PGF。为量化 PGF,进行了角度测量(PGA),顶点以视神经为中心,与玻璃体边界相切。对 IIH 患者和健康对照组的 PGA 测量结果进行了比较。此外,还使用 ROC 分析评估了 PGA 测量在检测 PGF 方面的诊断准确性:比较了 31 名 IIH 患者(37.3 ± 12.3 岁,29 名女性)和 28 名对照组(33.3 ± 11.8 岁,21 名女性)。39%的IIH患者体内存在PGF,而对照组中则没有。PGA3mm测量值在IIH和对照组之间存在明显差异(116.5°±5.5 vs. 111.7°±2.9;P 3mm临界值≥118.5°可区分IIH患者和对照组,特异性为100%,灵敏度为37.5%):结论:经眶超声可用于检测和量化 IIH 患者的 PGF。结论:经眶超声可用于检测和定量 IIH 患者的 PGF。需要通过扩大队列和盲法设计的前瞻性多中心研究来验证这些初步发现,并确认经眶超声在评估 IIH 患者 PGF 方面的诊断效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transorbital B-mode ultrasound for the assessment of posterior globe flattening in idiopathic intracranial hypertension: a pilot study.

Background: Posterior globe flattening (PGF) is a specific neuroimaging sign in patients with idiopathic intracranial hypertension (IIH), but its detection is based on subjective qualitative neuroradiological assessment. This study sought to evaluate the utility of transorbital ultrasound to detect and quantify PGF in IIH patients using the Posterior Globe Angle (PGA).

Methods: Consecutive IIH patients and healthy controls were enrolled in a prospective case-control study. Transorbital ultrasound was performed to assess the presence of PGF. For quantification of PGF, an angular measurement (PGA) was performed with the vertex centering the optic nerve at a predefined distance from the lamina cribrosa and angle legs tangentially aligned to the borders of the vitreous body. PGA measurements were compared between IIH patients and healthy controls. Additionally, the diagnostic accuracy of PGA measurements in detecting PGF was evaluated using ROC analysis.

Results: Thirty-one IIH patients (37.3 ± 12.3 years, 29 female) and 28 controls (33.3 ± 11.8 years, 21 female) were compared. PGF was present in 39% of IIH patients and absent in the control group. PGA3mm measurements significantly differed between IIH and controls (116.5° ± 5.5 vs. 111.7° ± 2.9; p < 0.001). A PGA3mm cutoff of ≥ 118.5° distinguished IIH patients from controls with 100% specificity, while retaining a sensitivity of 37.5%.

Conclusions: Transorbital ultrasound may be applied to detect and quantify PGF in IIH patients. Prospective, multicenter studies with extended cohorts and blinded design are needed to validate these preliminary findings and confirm the diagnostic utility of transorbital ultrasound for the assessment of PGF in IIH.

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来源期刊
Ultrasound Journal
Ultrasound Journal Health Professions-Radiological and Ultrasound Technology
CiteScore
6.80
自引率
2.90%
发文量
45
审稿时长
22 weeks
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