胆固醇基三唑合成及其生物应用的最新进展。

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Steroids Pub Date : 2024-08-16 DOI:10.1016/j.steroids.2024.109499

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引用次数: 0

摘要

注重药理和膜渗透性的双头弹头可为药物化学做出巨大贡献。在过去的几十年里，人们对类固醇杂环共轭物作为治疗各种疾病的可能药物进行了大量研究。20 世纪下半叶，以胆固醇为基础的杂环分子研究取得了成功。鉴于各种三唑类化合物的生物学意义，出现了与胆固醇融合的研究。本综述旨在探讨 2010 年至 2023 年期间胆固醇基三唑类化合物的化学性质及其在药物化学中的意义。

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Recent advances in the synthesis of cholesterol-based triazoles and their biological applications

Double-headed warheads focusing on the pharmacological aspects as well as membrane permeability can contribute a lot to medicinal chemistry. Over the past few decades, a lot of research has been conducted on steroid-heterocycle conjugates as possible therapeutic agents against a variety of disorders. In the second half of the 20th century, successful research was conducted on cholesterol-based heterocyclic moieties. Keeping in view the biological significance of various triazoles, research on fusion with cholesterol has emerged. This review has been designed to explore the chemistry of cholesterol-based triazoles for the duration from 2010 to 2023 and their significance in medicinal chemistry.

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.