丙酮酸激酶 M2 在调节败血症中的作用（综述）。

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Molecular medicine reports Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI:10.3892/mmr.2024.13309

Yifei Hu, Jing Tang, Qiao Xu, Zenghui Fang, Rongqing Li, Mengxuan Yang, Jie Zhao, Xin Chen

{"title":"丙酮酸激酶 M2 在调节败血症中的作用（综述）。","authors":"Yifei Hu, Jing Tang, Qiao Xu, Zenghui Fang, Rongqing Li, Mengxuan Yang, Jie Zhao, Xin Chen","doi":"10.3892/mmr.2024.13309","DOIUrl":null,"url":null,"abstract":"Glycolysis occurs in all living organisms as a form of energy supply. Pyruvate kinase M2 (PKM2) is one of the rate‑limiting enzymes in the glycolytic process. PKM2 is considered to serve an important role in several terminal diseases, including sepsis. However, to the best of our knowledge, the specific mechanistic role of PKM2 in sepsis remains to be systematically summarised. Therefore, the present review aims to summarise the roles of PKM2 in sepsis progression. In addition, potential treatment strategies for patients with sepsis are discussed. The present review hopes to lay the groundwork for studying the role of PKM2 and developing therapeutic strategies against metabolic disorders that occur during sepsis.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350625/pdf/","citationCount":"0","resultStr":"{\"title\":\"Role of pyruvate kinase M2 in regulating sepsis (Review).\",\"authors\":\"Yifei Hu, Jing Tang, Qiao Xu, Zenghui Fang, Rongqing Li, Mengxuan Yang, Jie Zhao, Xin Chen\",\"doi\":\"10.3892/mmr.2024.13309\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Glycolysis occurs in all living organisms as a form of energy supply. Pyruvate kinase M2 (PKM2) is one of the rate‑limiting enzymes in the glycolytic process. PKM2 is considered to serve an important role in several terminal diseases, including sepsis. However, to the best of our knowledge, the specific mechanistic role of PKM2 in sepsis remains to be systematically summarised. Therefore, the present review aims to summarise the roles of PKM2 in sepsis progression. In addition, potential treatment strategies for patients with sepsis are discussed. The present review hopes to lay the groundwork for studying the role of PKM2 and developing therapeutic strategies against metabolic disorders that occur during sepsis.\",\"PeriodicalId\":18818,\"journal\":{\"name\":\"Molecular medicine reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350625/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular medicine reports\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3892/mmr.2024.13309\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular medicine reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3892/mmr.2024.13309","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/19 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

糖酵解作为一种能量供应形式存在于所有生物体内。丙酮酸激酶 M2（PKM2）是糖酵解过程中的限速酶之一。人们认为，PKM2 在包括败血症在内的多种末期疾病中发挥着重要作用。然而，据我们所知，PKM2 在败血症中的具体机制作用仍有待系统总结。因此，本综述旨在总结 PKM2 在败血症进展中的作用。此外，还讨论了脓毒症患者的潜在治疗策略。本综述希望为研究 PKM2 的作用和开发针对脓毒症期间发生的代谢紊乱的治疗策略奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Role of pyruvate kinase M2 in regulating sepsis (Review).

Glycolysis occurs in all living organisms as a form of energy supply. Pyruvate kinase M2 (PKM2) is one of the rate‑limiting enzymes in the glycolytic process. PKM2 is considered to serve an important role in several terminal diseases, including sepsis. However, to the best of our knowledge, the specific mechanistic role of PKM2 in sepsis remains to be systematically summarised. Therefore, the present review aims to summarise the roles of PKM2 in sepsis progression. In addition, potential treatment strategies for patients with sepsis are discussed. The present review hopes to lay the groundwork for studying the role of PKM2 and developing therapeutic strategies against metabolic disorders that occur during sepsis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Molecular medicine reports 医学-病理学

CiteScore

7.60

自引率

0.00%

发文量

321

审稿时长

1.5 months

期刊介绍： Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.